Insulin-like growth factor and growth hormone receptor in nephrotic rats

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dc.contributor.authorThabet, M. A.en
dc.contributor.authorChalla, A.en
dc.contributor.authorChan, W.en
dc.contributor.authorLiu, F.en
dc.contributor.authorHintz, R. L.en
dc.contributor.authorChan, J. C.en
dc.date.accessioned2015-11-24T19:09:40Z
dc.date.available2015-11-24T19:09:40Z
dc.identifier.issn0002-9513-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20730
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectBlotting, Westernen
dc.subjectCarrier Proteins/metabolismen
dc.subjectFemaleen
dc.subjectInsulin-Like Growth Factor Binding Proteinsen
dc.subjectInsulin-Like Growth Factor I/geneticsen
dc.subjectLiver/metabolismen
dc.subjectNephrotic Syndrome/*blood/chemically induced/metabolismen
dc.subjectPuromycinen
dc.subjectRNA, Messenger/metabolismen
dc.subjectRatsen
dc.subjectRats, Sprague-Dawleyen
dc.subjectReceptors, Somatotropin/genetics/*metabolismen
dc.subjectSomatomedins/*metabolismen
dc.titleInsulin-like growth factor and growth hormone receptor in nephrotic ratsen
heal.abstractIn an attempt to elucidate the mechanism of growth retardation in the nephrotic syndrome, specific serum and hepatic growth factors were measured in Sprague-Dawley rats in which nephrotic syndrome was produced by administration of puromycin (1.5 mg.100 g body wt-1.day-1) for 12 days. On the 13th day, the results of these nephrotic animals were compared with those of an equal number of pair-fed and control animals: the mean dietary intake of the nephrotic group was 71% that of the control group (P < 0.001). Serum insulin-like growth factor (IGF) binding protein-3 was significantly reduced (P < 0.005) in the nephrotic rats, compared with the pair-fed and the control groups. Hepatic IGF-I mRNA in the nephrotic rats averaged 36% that of control (P < 0.001) and 46% that of the pair-fed animals (P < 0.001). Hepatic growth hormone receptor (GHr) mRNA in the nephrotic rats averaged 19% of that of the control (P < 0.001) and 27% of that of the pair-fed rats (P < 0.001). These results indicate that the growth retardation of the nephrotic rats may be associated with the significant decrease in IGF-I mRNA and reduction in GHr mRNA.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/7508192-
heal.journalNameAm J Physiolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1994-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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