Drug delivery into the human brain
| dc.contributor.author | Linninger A. A., MB. R. Somayaji, Xenos M., Kondapalli S. | en |
| dc.date.accessioned | 2015-11-24T17:23:06Z | |
| dc.date.available | 2015-11-24T17:23:06Z | |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/12698 | |
| dc.rights | Default Licence | - |
| dc.subject | Porous medium flow, human brain, drug infusion, patient-specific approach | en |
| dc.title | Drug delivery into the human brain | en |
| heal.abstract | Large proteins for the treatment of diseases such as Parkinson s, Alzheimer s and other disorders affecting the central nervous system (CNS) cannot easily penetrate the brain blood barrier (BBB). As an alternative to delivery through the blood stream, drugs may be inserted into the brain tissue directly using invasive release techniques. Direct injection is expected to gain importance in advanced medical treatment options such as convection-enhanced treatment of chronic diseases of the CNS, introduction of highly toxic agents in chemotherapy and gene-therapy by viral vectors. This presentation proposes a rigorous analysis of the transport phenomena effectuated by different drug release techniques. Various injection policies and effects in terms of drug perfusion rates, penetration depths and sustained drug concentrations in specific target area in the brain will be studied. Special attention will be given to studying the impact of design variables of the therapy (catheter tip, flow rate and concentration) on achievable treatment volumes. The advantages of a patient-specific approach rendering accurately the brain dimensions and physiology of each individual will be highlighted. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://cache.org/site/news_stand/fall05/fall2005_drugdelivery.pdf | - |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Μαθηματικών | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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