An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments

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dc.contributor.authorYang, Y.en
dc.contributor.authorDowling, J.en
dc.contributor.authorYu, Q. C.en
dc.contributor.authorKouklis, P.en
dc.contributor.authorCleveland, D. W.en
dc.contributor.authorFuchs, E.en
dc.date.accessioned2015-11-24T19:36:33Z
dc.date.available2015-11-24T19:36:33Z
dc.identifier.issn0092-8674-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23899
dc.rightsDefault Licence-
dc.subjectActin Cytoskeleton/*chemistryen
dc.subjectAlternative Splicingen
dc.subjectAnimalsen
dc.subjectAutoantigens/*physiologyen
dc.subjectBrain Chemistryen
dc.subject*Carrier Proteinsen
dc.subject*Collagenen
dc.subject*Cytoskeletal Proteinsen
dc.subjectFluorescent Antibody Techniqueen
dc.subjectGanglia, Spinal/ultrastructureen
dc.subjectGene Expressionen
dc.subjectHumansen
dc.subjectIn Situ Hybridizationen
dc.subjectIntermediate Filaments/*chemistryen
dc.subjectMiceen
dc.subjectMice, Mutant Strainsen
dc.subjectMicrofilament Proteins/*physiologyen
dc.subjectMolecular Weighten
dc.subjectNerve Tissue Proteins/*chemistryen
dc.subjectNeurofilament Proteins/*metabolismen
dc.subjectNeurons, Afferent/*ultrastructureen
dc.subject*Non-Fibrillar Collagensen
dc.subjectProtein Bindingen
dc.subjectRNA, Messenger/geneticsen
dc.subjectSpinal Cord/chemistryen
dc.titleAn essential cytoskeletal linker protein connecting actin microfilaments to intermediate filamentsen
heal.abstractTypified by rapid degeneration of sensory neurons, dystonia musculorum mice have a defective BPAG1 gene, known to be expressed in epidermis. We report a neuronal splice form, BPAG1n, which localizes to sensory axons. Both isoforms have a coiled-coil rod, followed by a carboxy domain that associates with intermediate filaments. However, the amino terminus of BPAG1n differs from BPAG1e in that it contains a functional actin-binding domain. In transfected cells, BPAG1n coaligns neurofilaments and microfilaments, establishing this as a cytoskeletal protein interconnecting actin and intermediate filament cytoskeletons. In BPAG1 null mice, axonal architecture is markedly perturbed, consistent with a failure to tether neurofilaments to the actin cytoskeleton and underscoring the physiological relevance of this protein.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8752219-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0092867400801385/1-s2.0-S0092867400801385-main.pdf?_tid=42f9eec73d9d06ec0e9b185a88aa5a04&acdnat=1332933311_5c5df00e8754934d166d54290fd78241-
heal.journalNameCellen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1996-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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