The effects of nebulized salbutamol, external positive end-expiratory pressure, and their combination on respiratory mechanics, hemodynamics, and gas exchange in mechanically ventilated chronic obstructive pulmonary disease patients

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dc.contributor.authorTzoufi, M.en
dc.contributor.authorMentzelopoulos, S. D.en
dc.contributor.authorRoussos, C.en
dc.contributor.authorArmaganidis, A.en
dc.date.accessioned2015-11-24T19:41:41Z
dc.date.available2015-11-24T19:41:41Z
dc.identifier.issn0003-2999-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24520
dc.rightsDefault Licence-
dc.subjectAerosolsen
dc.subjectAgeden
dc.subjectAlbuterol/administration & dosage/*pharmacologyen
dc.subjectBody Weight/physiologyen
dc.subjectBronchodilator Agents/administration & dosage/*pharmacologyen
dc.subjectElectrocardiographyen
dc.subjectFemaleen
dc.subjectFunctional Residual Capacityen
dc.subjectHemodynamics/drug effects/*physiologyen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subject*Positive-Pressure Respirationen
dc.subjectPulmonary Disease, Chronic Obstructive/drug therapy/*physiopathology/*therapyen
dc.subjectPulmonary Gas Exchange/drug effects/*physiologyen
dc.subjectRespiratory Mechanics/drug effects/*physiologyen
dc.titleThe effects of nebulized salbutamol, external positive end-expiratory pressure, and their combination on respiratory mechanics, hemodynamics, and gas exchange in mechanically ventilated chronic obstructive pulmonary disease patientsen
heal.abstractWe hypothesized that combined salbutamol and external positive end-expiratory pressure (PEEPe) may present additive benefits in chronic obstructive pulmonary disease (COPD) exacerbation. In 10 anesthetized, mechanically ventilated, and bronchodilator-responsive COPD patients exhibiting moderate intrinsic PEEP (PEEPi), we assessed respiratory system (rs) mechanics, hemodynamics, and gas exchange at (a) baseline (zero PEEPe [ZEEPe]), (b) 30 min after 5 mg of nebulized salbutamol administration (ZEEPe-S), (c) 30 min after setting PEEPe at baseline PEEPi level (PEEPe), and (d) 30 min after 5 mg of nebulized salbutamol administration with PEEPe maintained unchanged (PEEPe-S). Return of determined variable values to baseline values was confirmed before PEEPe application. Relative to ZEEPe, (a) at ZEEP-S, PEEPi (4.8 +/- 0.7 versus 7.0 +/- 1.1 cm H(2)O), functional residual capacity change (115.6 +/- 23.1 versus 202.1 +/- 46.0 mL), minimal rs (airway) resistance (9.3 +/- 1.4 versus 11.8 +/- 2.2 cm H(2)O.L(-1).s(-1)), and additional rs resistance (5.2 +/- 1.4 versus 7.2 +/- 1.3 cm H(2)O.L(-1).s(-1)) were reduced (P < 0.01), and hemodynamics were improved; (b) at PEEPe, PEEPi (3.7 +/- 1.3 cm H(2)O) was reduced (P < 0.01), and gas exchange was improved; and (c) at PEEPe-S, PEEPi (2.0 +/- 1.2 cm H(2)O) was minimized, and rs mechanics (static rs elastance included), hemodynamics, and gas exchange were improved. Conclusively, in carefully preselected COPD patients, bronchodilation/PEEPe exhibits additive benefits.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1213/01.ane.0000167276.92462.ba-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16116002-
heal.journalNameAnesth Analgen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2005-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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