Effect of Varying Concentrations of Follicle-Stimulating-Hormone on the Production of Gonadotropin Surge Attenuating Factor (Gnsaf) in Women
Φόρτωση...
Ημερομηνία
Συγγραφείς
Messinis, I. E.
Lolis, D.
Papadopoulos, L.
Tsahalina, T.
Papanikolaou, N.
Seferiadis, K.
Templeton, A. A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Clin Endocrinol (Oxf)
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
OBJECTIVE We studied the time-course of production of gonadotrophin surge attenuating factor (GnSAF) in relation to varying serum concentrations of FSH in women. DESIGN Normally cycling women were investigated in four cycles, i.e. a spontaneous cycle treated with placebo (cycle P) and three cycles treated with three different FSH dosages (1 ampoule, cycle 1; 3 ampoules, cycle 3 and 6 ampoules, cycle 6). Placebo or FSH were given as a single i.m. injection on cycle day 2 (0900 h). The response of LH to an i.v. injection of 10 mug GnRH (GnSAF bioactivity) was investigated 4, 8, 12 and 24 hours after the injection of placebo or FSH. PATIENTS Six normally ovulating women with long-standing unexplained infertility were studied. The women were used as their own controls during the cycle treated with placebo. MEASUREMENTS Pituitary response to GnRH was calculated as the net increase in LH at 30 minutes (DELTALH) above the basal value. RESULTS Serum FSH concentrations increased after the injection of FSH in a dose dependent manner. Compared with cycle P, DELTALH was significantly attenuated in cycle 3 and cycle 6 at 8,12 and 24 hours and in cycle 1 at 12 hours after the injection of FSH. Basal concentrations of oestradiol (E2) and LH did not differ significantly among the four cycles at any point except in cycle 6 at 24 hours after the FSH injection when E2 values were significantly higher and LH values significantly lower than in cycle-P. CONCLUSIONS These results suggest that GnSAF bioactivity increases significantly as early as 8 hours from a single injection of FSH before any significant increase in serum E2 values. We conclude that in women the effect of FSH on the production of GnSAF in the early follicular phase is concentration dependent.
Περιγραφή
Λέξεις-κλειδιά
self-priming action, superovulated women, invivo, lhrh, release, ovary, fluid
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://A1993LK72100006
http://onlinelibrary.wiley.com/store/10.1111/j.1365-2265.1993.tb01749.x/asset/j.1365-2265.1993.tb01749.x.pdf?v=1&t=h0xqm5a1&s=07e18ed66b3e9f8a47d0ab3fa22008040bf6c5db
http://onlinelibrary.wiley.com/store/10.1111/j.1365-2265.1993.tb01749.x/asset/j.1365-2265.1993.tb01749.x.pdf?v=1&t=h0xqm5a1&s=07e18ed66b3e9f8a47d0ab3fa22008040bf6c5db
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών