Cathepsin-D and c-erb-B 2 have an additive prognostic value for breast cancer patients

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dc.contributor.authorScorilas, A.en
dc.contributor.authorYotis, J.en
dc.contributor.authorGouriotis, D.en
dc.contributor.authorKeramopoulos, A.en
dc.contributor.authorAmpela, K.en
dc.contributor.authorTrangas, T.en
dc.contributor.authorTalieri, M.en
dc.date.accessioned2015-11-24T16:35:02Z
dc.date.available2015-11-24T16:35:02Z
dc.identifier.issn0250-7005-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/7889
dc.rightsDefault Licence-
dc.subjectBreast Neoplasms/*diagnosis/pathologyen
dc.subjectCathepsin D/*analysisen
dc.subjectCytosol/chemistryen
dc.subjectFemaleen
dc.subjectGene Amplificationen
dc.subjectGenes, mycen
dc.subjectHumansen
dc.subjectImmunoradiometric Assayen
dc.subjectLymphatic Metastasisen
dc.subjectMenopauseen
dc.subjectPrognosisen
dc.subjectProto-Oncogene Proteins/*analysisen
dc.subjectReceptor, Epidermalen
dc.titleCathepsin-D and c-erb-B 2 have an additive prognostic value for breast cancer patientsen
heal.abstractIn breast cancer, axillary lymph node invasiveness is the major prognostic factor in predicting relapse and metastasis. Nevertheless, since 30% of node-negative tumours also relapse, it is necessary to develop other independent prognostic factors. Oncogene amplification and overexpression as well as the level of cathepsin-D have been proposed as additional prognostic factors. Recent studies suggest that the acidic lysosomal proteinase cath-D, present in all cells and known to be secreted in breast cancer cells, may be implicated in the process of tumour invasion and metastasis. We have compared the cytosolic cath-D level with the amplification and the overexpression of the oncogenes c-myc and c-erb-b-2 in 62 breast carcinomas (52 primary and 10 metastatic). Using a cut-off level of 60 pmol/mg protein, the status of cath-D showed a positive correlation with c-myc amplification (P = 0.01) or overexpression (P = 0.02). In contrast, no correlation was found between cath-D and c-erb-B-2 amplification or overexpression. Also, no correlation was found between cath-D and established prognostic factors such as node invasiveness, steroid receptors, grade and menopausal status. Nevertheless, a weak correlation was found between cath-D levels and tumour status (P = 0.05). In conclusion, in breast cancer, a high cytosolic cath-D concentration is more frequent in tumours with c-myc amplification and overexpression but is dissociated from c-erb-B-2 amplification or overexpression, suggesting that the determination of cath-D, as well as the latter two markers, will have an additional prognostic value.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/7903524-
heal.journalNameAnticancer Resen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate1993-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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