Association between angiotensin-converting enzyme insertion/deletion gene polymorphism and atrial fibrillation: a meta-analysis

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dc.contributor.authorLiu, T.en
dc.contributor.authorKorantzopoulos, P.en
dc.contributor.authorXu, G.en
dc.contributor.authorShehata, M.en
dc.contributor.authorLi, D.en
dc.contributor.authorWang, X.en
dc.contributor.authorLi, G.en
dc.date.accessioned2015-11-24T19:35:04Z
dc.date.available2015-11-24T19:35:04Z
dc.identifier.issn1532-2092-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23675
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAtrial Fibrillation/epidemiology/*genetics/physiopathologyen
dc.subjectCase-Control Studiesen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectINDEL Mutation/*geneticsen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPeptidyl-Dipeptidase A/*geneticsen
dc.subjectPolymorphism, Genetic/geneticsen
dc.subjectRenin-Angiotensin System/physiologyen
dc.subjectRisk Factorsen
dc.titleAssociation between angiotensin-converting enzyme insertion/deletion gene polymorphism and atrial fibrillation: a meta-analysisen
heal.abstractAIMS: Recent observations have raised concerns regarding the activation of the renin-angiotensin system and the development of atrial fibrillation (AF). Some initial studies indicated an association between an angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphism and AF, however, the results have been inconsistent. Our aim was to perform a meta-analysis of relevant studies to assess the validity of this association. METHODS AND RESULTS: PubMed, Cochrane clinical trials database, and EMBASE were searched through July 2009, and a manual search was also performed. Of the 68 initially identified studies, 18 case-control studies with 7577 patients were finally analysed. No statistically significant associations were found between the ACE I/D polymorphism and AF risk in the genetic additive model and dominant model, whereas a significant association was observed in the recessive model. A significant heterogeneity between individual studies was evident in all three models. Subgroup analyses showed a strong association between the ACE I/D polymorphism and hypertensive AF without significant heterogeneity. CONCLUSION: Our meta-analysis suggests that there is insufficient evidence to demonstrate an association between ACE I/D polymorphism and AF risk. However, there seems to be a significant association between ACE I/D gene polymorphic variation and AF in patients with hypertension. Additional studies are warranted to further explore this association in ethnically diverse populations and varied cardiovascular substrates.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1093/europace/euq407-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21076147-
heal.identifier.secondaryhttp://europace.oxfordjournals.org/content/13/3/346.full.pdf-
heal.journalNameEuropaceen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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