Carboplatin and Paclitaxel versus Cisplatin, Paclitaxel and Doxorubicin for first-line chemotherapy of Advanced Ovarian Cancer: A Hellenic Cooperative Oncology Group (HeCOG) study

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dc.contributor.authorAravantinos, G.en
dc.contributor.authorFountzilas, G.en
dc.contributor.authorBamias, A.en
dc.contributor.authorGrimani, I.en
dc.contributor.authorRizos, S.en
dc.contributor.authorKalofonos, H. P.en
dc.contributor.authorSkarlos, D. V.en
dc.contributor.authorEconomopoulos, T.en
dc.contributor.authorKosmidis, P. A.en
dc.contributor.authorStathopoulos, G. P.en
dc.contributor.authorBriasoulis, E.en
dc.contributor.authorPectasides, D.en
dc.contributor.authorSamantas, E.en
dc.contributor.authorTimotheadou, E.en
dc.contributor.authorPapadimitriou, C.en
dc.contributor.authorPapanikolaou, A.en
dc.contributor.authorOnyenadum, A.en
dc.contributor.authorPapakostas, P.en
dc.contributor.authorBafaloukos, D.en
dc.contributor.authorDimopoulos, M. A.en
dc.date.accessioned2015-11-24T17:58:06Z
dc.date.available2015-11-24T17:58:06Z
dc.identifier.issn0959-8049-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/15827
dc.rightsDefault Licence-
dc.subjectadvanceden
dc.subjectanthracyclineen
dc.subjectcarboplatinen
dc.subjectcisplatinen
dc.subjectchemotherapyen
dc.subjectdoxorubicinen
dc.subjectphase-iien
dc.subjectinitial treatmenten
dc.subjectintergroup trialen
dc.subjectstage-iiien
dc.subjectcyclophosphamideen
dc.subjectcarcinomaen
dc.subjectmetaanalysisen
dc.subjectsafetyen
dc.titleCarboplatin and Paclitaxel versus Cisplatin, Paclitaxel and Doxorubicin for first-line chemotherapy of Advanced Ovarian Cancer: A Hellenic Cooperative Oncology Group (HeCOG) studyen
heal.abstractIntroduction: The combination of Carboplatin and Paclitaxel is considered the standard of care as initial chemotherapy for Advanced Ovarian Cancer (AOC). We compared this regimen with the combination of Cisplatin, Paclitaxel and Doxorubicin. Patients and methods: Patients with AOC were randomised to either six courses of Paclitaxel 175 mg/m(2) plus Carboplatin 7AUC or Paclitaxel at the same dose plus Cisplatin 75 mg/m(2) plus Doxorubicin 40 mg/m(2). Results: Analysis was performed on 451 patients. The treatment groups were well balanced with regard to patient and disease characteristics. Performance status (PS) was better in the anthracycline arm. In terms of severe toxicity, the only significant difference between the two groups was the development of febrile neutropaenia in the anthracycline arm. Overall response rate was similar in both groups. With a median follow-up of 57.5 months, a marginal significance towards improved Progression-Free Survival (PFS) was noted in favour of the anthracycline arm, whilst there was no difference in overall survival. In multivariate analysis the hazard of disease progression at any time was significantly decreased by 25.5% for patients of the anthracycline arm. Conclusion: The combination of Cisplatin, Paclitaxel and Doxorubicin demonstrates a marginal PFS improvement, but no additional survival benefit when compared with the standard Carboplatin/Paclitaxel regimen. (c) 2008 Elsevier Ltd. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000261020800014-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0959804908004589/1-s2.0-S0959804908004589-main.pdf?_tid=6a3ad8f4e718b385daf68e049bde9230&acdnat=1334230973_d3c9d41649026f62ca0476191b97b4a3-
heal.journalNameEuropean Journal of Canceren
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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