Platinum(II) and palladium(II) complexes of pyridine-2-carbaldehyde thiosemicarbazone as alternative antiherpes simplex virus agents
| dc.contributor.author | Kovala-Demertzi, D. | en |
| dc.contributor.author | Varadinova, T. | en |
| dc.contributor.author | Genova, P. | en |
| dc.contributor.author | Souza, P. | en |
| dc.contributor.author | Demertzis, M. A. | en |
| dc.date.accessioned | 2015-11-24T16:45:04Z | |
| dc.date.available | 2015-11-24T16:45:04Z | |
| dc.identifier.issn | 1565-3633 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/8878 | |
| dc.rights | Default Licence | - |
| dc.subject | spectral properties | en |
| dc.subject | 2-acetyl pyridine | en |
| dc.subject | crystal-structure | en |
| dc.subject | ribonucleotide reductase | en |
| dc.subject | antiviral activity | en |
| dc.subject | type-2 infection | en |
| dc.subject | penciclovir | en |
| dc.subject | resistance | en |
| dc.subject | hiv-1 | en |
| dc.subject | acquisition | en |
| dc.title | Platinum(II) and palladium(II) complexes of pyridine-2-carbaldehyde thiosemicarbazone as alternative antiherpes simplex virus agents | en |
| heal.abstract | The cytotoxicity and the antivirus activity of Pd(II) and Pt(II) complexes with pyridine-2-carbaldehyde thiosemicarbazone (HFoTsc) against HSV replication were evaluated on four HSV strains - two wt strains Victoria (HSV-1) and BJA (HSV-2) and two ACV(R) mutants with different tk gene mutations R-100 (TK(A), HSV-1) and PU (TK(N), HSV-2). The experiments were performed on continuous MDBK cells and four HSV 1 and HSV 2 strains were used, two sensitive to acyclovir and two resistant mutants. The five complexes of HFoTsc, [Pt(FoTsc)Cl], [Pt(FoTsc)(H(2)FoTsc)]Cl(2), [Pt(FoTsc)(2)], [Pd(FoTsc)(H(2)FoTsc)]Cl(2), and [Pd(FoTsc)(2)], were found to be effective inhibitors of HSV replication. The most promising, active, and selective anti-HSV agent was found to be complex [Pt(FoTsc)(H(2)FoTsc)]Cl(2). This complex could be useful in the treatment of HSV infections, since it is resistant to ACV mutants. PCR study of immediate early 300 bp ReIV Us1 region reveals that the complex [Pt(FoTsc)(H(2)FoTsc)]Cl(2) specifically suppressed wt HSV-1 genome 2 hours after the infection, not inducing apoptosis/necrosis on the 8 hours after virus infection. The target was found to be most probably the viral, instead of the host cell DNA. Copyright (C) 2007 D. Kovala-Demertzi et al. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | Doi 10.1155/2007/56165 | - |
| heal.identifier.secondary | <Go to ISI>://000244557200001 | - |
| heal.identifier.secondary | http://downloads.hindawi.com/journals/bca/2007/056165.pdf | - |
| heal.journalName | Bioinorg Chem Appl | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2007 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
Αρχεία
Πρωτότυπος φάκελος/πακέτο
1 - 1 of 1
Φόρτωση...
- Ονομα:
- Kovala-Demertzi-2007-Platinum(II) and pal.pdf
- Μέγεθος:
- 565.73 KB
- Μορφότυπο:
- Adobe Portable Document Format
Φάκελος/Πακέτο αδειών
1 - 1 of 1
Φόρτωση...
- Ονομα:
- license.txt
- Μέγεθος:
- 1.74 KB
- Μορφότυπο:
- Item-specific license agreed upon to submission
- Περιγραφή: