Surface topography and ultrastructure correlation between human breast infiltrating ductal carcinoma of non special type and coexisting human breast infiltrating ductal carcinoma of non special type with in situ comedo carcinoma
Φόρτωση...
Ημερομηνία
Συγγραφείς
Voloudakis, G. E.
Baltatzis, G. E.
Stefanou, D.
Agnantis, N. J.
Voloudakis-Baltatzis, I. E.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J BUON
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
PURPOSE: To examine the topographical and ultrastructural correlations and differences between breast infiltrating ductal carcinoma (DC) non-special type (NST) and coexisting infiltrating DC NST with in situ comedo, in order to possibly detect differences in their metastatic potential. MATERIALS AND METHODS: The material examined derived from 22 women with breast cancer. Sixteen breast infiltrating DC NST tissue samples and 6 breast infiltrating DC NST with in situ comedo were studied with primary culture techniques, using transmission and scanning electron microscopy methods. RESULTS: The surface topography from infiltrating DC NST cells showed microvilli, blebs, ruffles, short and long projections. These features were absent in the normal breast cells. The intensity of these features was dependent on several histological characteristics. Also, the above features in coexisting DC NST with in situ comedo were related to more aggressive cases. The findings concerning the surface topography features have been also found in the ultrastructural level. A very interesting point was that these features consisted partly of cytoplasmic material. CONCLUSION: We believe that the presence of the features described above might be related to the metastatic potential of breast cancer and in particular to DC NST with in situ comedo.
Περιγραφή
Λέξεις-κλειδιά
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/17472243
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής