T(2) relaxation rate of basal ganglia and cortex in patients with beta-thalassaemia major
| dc.contributor.author | Metafratzi, Z. | en |
| dc.contributor.author | Argyropoulou, M. I. | en |
| dc.contributor.author | Kiortsis, D. N. | en |
| dc.contributor.author | Tsampoulas, C. | en |
| dc.contributor.author | Chaliassos, N. | en |
| dc.contributor.author | Efremidis, S. C. | en |
| dc.date.accessioned | 2015-11-24T19:43:09Z | |
| dc.date.available | 2015-11-24T19:43:09Z | |
| dc.identifier.issn | 0007-1285 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24728 | |
| dc.rights | Default Licence | - |
| dc.subject | Adolescent | en |
| dc.subject | Adult | en |
| dc.subject | Basal Ganglia/*metabolism | en |
| dc.subject | Blood-Brain Barrier/physiology | en |
| dc.subject | Case-Control Studies | en |
| dc.subject | Cerebral Cortex/*metabolism | en |
| dc.subject | Child | en |
| dc.subject | Female | en |
| dc.subject | Ferritins/analysis/metabolism | en |
| dc.subject | Humans | en |
| dc.subject | Iron Overload/complications/diagnosis/metabolism | en |
| dc.subject | *Magnetic Resonance Imaging/methods | en |
| dc.subject | Male | en |
| dc.subject | Statistics, Nonparametric | en |
| dc.subject | beta-Thalassemia/blood/complications/*diagnosis | en |
| dc.title | T(2) relaxation rate of basal ganglia and cortex in patients with beta-thalassaemia major | en |
| heal.abstract | In thalassaemic patients, neurophysiological disturbances have been associated with high serum ferritin levels and desferrioxamine therapy. In the presence of a magnetic field, ferritin, the main iron storage protein, induces a preferential decrease of the T(2) relaxation time. The purpose of this study was to evaluate thalassaemic patients for brain iron deposition by assessing the T(2) relaxation rate (1/T(2)) of the grey matter. 41 thalassaemic patients (age range 8.5-44 years, mean 24 years) and 58 age- and sex-matched controls were included in the study. Current serum ferritin levels were obtained. The 1/T(2) values of the cortex (motor and temporal) (mean 0.0122 ms(-1), SD 0.0004), putamen (mean 0.0137 ms(-1), SD 0.0004) and caudate nucleus (mean 0.0132 ms(-1), SD 0.0003) were higher in patients compared with the controls (mean 0.0110 ms(-1), SD 0.0004; mean 0.0120 ms(-1), SD 0.0005; mean 0.0117 ms(-1), SD 0.0003, respectively) (p<0.001 for all parameters). No statistically significant differences were found in the globus pallidus. No correlation was found between 1/T(2) and serum ferritin. The higher values of 1/T(2) in the cortex, putamen and caudate nucleus of thalassaemic patients probably reflect a higher iron deposition. The lack of differences in 1/T(2) of the globus pallidus might suggest that even in thalassaemic patients iron cannot exceed a saturation level. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/11388988 | - |
| heal.identifier.secondary | http://bjr.birjournals.org/content/74/881/407.full.pdf | - |
| heal.journalName | Br J Radiol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2001 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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