Sibutramine-associated adverse effects: a practical guide for its safe use
Φόρτωση...
Ημερομηνία
Συγγραφείς
Florentin, M.
Liberopoulos, E. N.
Elisaf, M. S.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Obesity Reviews
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Obesity is a multifactorial chronic disorder which comprises a serious health problem nowadays. The effective management of obesity is difficult in contemporary societies where abundance of hypercaloric food and sedentary lifestyle is the rule. Apart from lifestyle interventions, which include diet, exercise and behavioural treatment, weight-loss medications can also be used for the management of obesity. Sibutramine, a selective monoamine reuptake inhibitor, is a drug with established efficacy in sustained weight reduction and an overall favourable safety profile. However, its action on the sympathetic nervous system has linked sibutramine to blood pressure and heart rate elevations. These potentially adverse effects as well as other sibutramine-associated side effects and their possible underlying mechanisms are reviewed in the present article. Compelling evidence from the majority of data in the literature shows that sibutramine can be effectively used in conjunction with caloric restriction and exercise in obese patients. Hypertension, if adequately treated and frequently monitored, is not an absolute contraindication for the prescription of sibutramine.
Περιγραφή
Λέξεις-κλειδιά
Appetite Depressants/*adverse effects/therapeutic use, Cyclobutanes/*adverse effects/therapeutic use, Heart Rate/drug effects, Humans, Hypertension/chemically induced, Obesity/*drug therapy, Risk Assessment, Safety
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/18034790
http://onlinelibrary.wiley.com/store/10.1111/j.1467-789X.2007.00425.x/asset/j.1467-789X.2007.00425.x.pdf?v=1&t=h0td6ni8&s=d563685bc9b4f72ad1af76b33db0225b9a5cb3b6
http://onlinelibrary.wiley.com/store/10.1111/j.1467-789X.2007.00425.x/asset/j.1467-789X.2007.00425.x.pdf?v=1&t=h0td6ni8&s=d563685bc9b4f72ad1af76b33db0225b9a5cb3b6
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής