Elevated progesterone at initiation of stimulation is associated with a lower ongoing pregnancy rate after IVF using GnRH antagonists
| dc.contributor.author | Kolibianakis, E. M. | en |
| dc.contributor.author | Zikopoulos, K. | en |
| dc.contributor.author | Smitz, J. | en |
| dc.contributor.author | Camus, M. | en |
| dc.contributor.author | Tournaye, H. | en |
| dc.contributor.author | Van Steirteghem, A. C. | en |
| dc.contributor.author | Devroey, P. | en |
| dc.date.accessioned | 2015-11-24T19:19:59Z | |
| dc.date.available | 2015-11-24T19:19:59Z | |
| dc.identifier.issn | 0268-1161 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22001 | |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Embryo Transfer | en |
| dc.subject | Female | en |
| dc.subject | *Fertilization in Vitro | en |
| dc.subject | Follicle Stimulating Hormone/therapeutic use | en |
| dc.subject | Gonadotropin-Releasing Hormone/*antagonists & inhibitors | en |
| dc.subject | Humans | en |
| dc.subject | *Ovulation Induction | en |
| dc.subject | Pregnancy | en |
| dc.subject | *Pregnancy Rate | en |
| dc.subject | Progesterone/*blood | en |
| dc.subject | Prospective Studies | en |
| dc.subject | Recombinant Proteins/therapeutic use | en |
| dc.title | Elevated progesterone at initiation of stimulation is associated with a lower ongoing pregnancy rate after IVF using GnRH antagonists | en |
| heal.abstract | BACKGROUND: The objective of this prospective study was to assess the impact of elevated serum progesterone levels on day 2 of the cycle on pregnancy rates in patients treated by IVF using GnRH antagonists. METHODS: Ovarian stimulation was started on day 2 of the cycle if progesterone levels were normal (normal-P group, n = 390). In the presence of elevated progesterone, initiation of stimulation was postponed for 1 or 2 days (high-P group, n = 20) and was started if repeat progesterone levels returned to normal range (n = 16). Stimulation was performed with recombinant FSH (rFSH) and GnRH antagonist was always started on day 6 of stimulation. RESULTS: A significantly higher exposure to progesterone and a significantly lower exposure to estradiol was present in the high-P as compared with the normal-P group from day 1 to day 8 of stimulation. In addition, a significantly lower ongoing pregnancy rate both per started cycle (5.0% versus 31.8%; P = 0.01) and per embryo transfer (6.3% versus 36.9%; P = 0.01) was present in the high-P compared with the normal-P group, respectively. CONCLUSIONS: The presence of elevated serum progesterone on day 2 of the cycle is associated with a decreased chance of pregnancy in patients treated with rFSH and GnRH antagonists. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1093/humrep/deh272 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/15155603 | - |
| heal.identifier.secondary | http://humrep.oxfordjournals.org/content/19/7/1525.full.pdf | - |
| heal.journalName | Hum Reprod | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2004 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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