Disappearance of a growth hormone secreting macro adenoma during long-term somatostatin analogue administration and recurrence following somatostatin withdrawal

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dc.contributor.authorLivadas, S.en
dc.contributor.authorHadjidakis, D. J.en
dc.contributor.authorArgyropoulou, M. I.en
dc.contributor.authorStamatelatou, M.en
dc.contributor.authorKelekis, D.en
dc.contributor.authorRaptis, S. A.en
dc.date.accessioned2015-11-24T19:24:16Z
dc.date.available2015-11-24T19:24:16Z
dc.identifier.issn1109-3099-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22446
dc.rightsDefault Licence-
dc.subjectAcromegaly/drug therapyen
dc.subjectAdenoma/drug therapy/pathology/*secretionen
dc.subjectAntineoplastic Agents/*administration & dosageen
dc.subjectFemaleen
dc.subjectHuman Growth Hormone/*secretionen
dc.subjectHumansen
dc.subjectMagnetic Resonance Imagingen
dc.subjectMiddle Ageden
dc.subject*Neoplasm Recurrence, Localen
dc.subjectPeptides, Cyclic/*administration & dosageen
dc.subjectPituitary Neoplasms/drug therapy/pathology/*secretionen
dc.subjectSomatostatin/administration & dosage/*analogs & derivativesen
dc.titleDisappearance of a growth hormone secreting macro adenoma during long-term somatostatin analogue administration and recurrence following somatostatin withdrawalen
heal.abstractAcromegaly is caused by excessive growth hormone secretion, usually from a pituitary adenoma. The use of somatostatin analogues as primary or adjunctive therapy has been widely applied in the management of acromegaly. We are aware of only three reported cases of complete shrinkage of a pituitary adenoma after long-term analogue administration. However in these cases, the reduction in the dimension of the adenoma was obtained with the everyday use of somatostatin analogues and not with the newer longer acting formulations. We report a patient in whom long term (62 months) lanreotide-L.A.R administration resulted in complete disappearance of a growth hormone secreting pituitary macroadenoma, followed by recurrence of the adenoma six months post therapy discontinuation.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16728386-
heal.journalNameHormones (Athens)en
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2006-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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