Potential aetiological factors concerning the development of osteonecrosis of the femoral head
Φόρτωση...
Ημερομηνία
Συγγραφείς
Zalavras, C.
Dailiana, Z.
Elisaf, M. S.
Bairaktari, E.
Vlachogiannopoulos, P.
Katsaraki, A.
Malizos, K. N.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Eur J Clin Invest
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: The aetiology and pathogenesis of non-traumatic osteonecrosis (ON) of the femoral head have not been fully elucidated. The present study was conducted to evaluate the possible correlation of relevant haematological and biochemical factors with the development of ON. PATIENTS AND METHODS: Our investigation consisted of measurement of haematological indices and assessment of the biochemical and lipid profile of a study population of 68 patients with non-traumatic ON of the femoral head and 36 healthy controls. The disease was considered idiopathic in 17 and secondary in 51 patients. RESULTS: There were no statistically significant differences in the parameters measured among the idiopathic ON, secondary ON and control groups, except for globulins alpha1, alpha2 and beta, which were significantly increased in both patient groups, and apolipoprotein B (Apo B), which was increased in patients with idiopathic disease compared with the control group. Both patient groups presented increased von Willebrand factor (VWF) and lipoprotein (a) [Lp(a)] levels and decreased protein C and S concentrations, but without statistical significance. However, both patient groups exhibited a greater proportion of abnormal values of any of these parameters, in 58.9% of the idiopathic and in 62.7% of the secondary ON patients, compared with 8.3% of the controls. CONCLUSION: Our study underlines the potential association of abnormal values of protein C, protein S, VWF and Lp(a) with ON. To our knowledge this is the first reported association of VWF with the disease. The majority of both idiopathic and secondary ON patients in our series exhibits a thrombotic potential that adds further support to the postulation that intravascular coagulation is a major pathogenetic mechanism leading to the disease.
Περιγραφή
Λέξεις-κλειδιά
Adult, *Blood Coagulation, Blood Proteins/*analysis, Female, Femur Head Necrosis/*blood/*etiology, Humans, Lipids/blood, Male, Middle Aged, von Willebrand Factor/analysis
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/10691998
http://onlinelibrary.wiley.com/store/10.1046/j.1365-2362.2000.00621.x/asset/j.1365-2362.2000.00621.x.pdf?v=1&t=h0mamtdy&s=c8e11b16fad44ee6c6e405544d08e195e3a7cf3e
http://onlinelibrary.wiley.com/store/10.1046/j.1365-2362.2000.00621.x/asset/j.1365-2362.2000.00621.x.pdf?v=1&t=h0mamtdy&s=c8e11b16fad44ee6c6e405544d08e195e3a7cf3e
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής