The structure of the 5'-untranslated region of mammalian poly(A) polymerase-alpha mRNA suggests a mechanism of translational regulation

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dc.contributor.authorRapti, A.en
dc.contributor.authorTrangas, T.en
dc.contributor.authorSamiotaki, M.en
dc.contributor.authorIoannidis, P.en
dc.contributor.authorDimitriadis, E.en
dc.contributor.authorMeristoudis, C.en
dc.contributor.authorVeletza, S.en
dc.contributor.authorCourtis, N.en
dc.date.accessioned2015-11-24T16:34:30Z
dc.date.available2015-11-24T16:34:30Z
dc.identifier.issn1573-4919-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/7811
dc.rightsDefault Licence-
dc.subject*5' Untranslated Regionsen
dc.subjectBase Sequenceen
dc.subjectCell Lineen
dc.subjectConserved Sequenceen
dc.subjectExonsen
dc.subjectGC Rich Sequenceen
dc.subject*Gene Expression Regulation, Enzymologicen
dc.subjectHumansen
dc.subjectMolecular Sequence Dataen
dc.subjectMutationen
dc.subjectNucleic Acid Conformationen
dc.subjectOpen Reading Framesen
dc.subjectPolynucleotide Adenylylen
dc.titleThe structure of the 5'-untranslated region of mammalian poly(A) polymerase-alpha mRNA suggests a mechanism of translational regulationen
heal.abstractPoly(A)polymerase-alpha (PAPOLA) has been the most extensively investigated mammalian polyadenylating enzyme, mainly in regard to its multifaceted post-translational regulation. The possibility of translational regulation of this enzyme was addressed. The transcription start site was mapped and two uORFs, highly conserved among several species, were identified in the 211-bp long, GC-rich, 5' UTR of the PAPOLA mRNA. Mutation of the 5' proximal AUG resulted in increased translational efficiency of the adjacent coding sequence, whereas no significant effect was observed after mutation of the second AUG. These observations imply that translational regulation is among the conserved mechanisms regulating PAPOLA expression.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1007/s11010-010-0405-x-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/20174964-
heal.identifier.secondaryhttp://www.springerlink.com/content/973231537j128887/fulltext.pdf-
heal.journalNameMol Cell Biochemen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2010-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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