Effect of ezetimibe monotherapy on the concentration of lipoprotein subfractions in patients with primary dyslipidaemia

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dc.contributor.authorKalogirou, M.en
dc.contributor.authorTsimihodimos, V.en
dc.contributor.authorGazi, I.en
dc.contributor.authorFilippatos, T.en
dc.contributor.authorSaougos, V.en
dc.contributor.authorTselepis, A. D.en
dc.contributor.authorMikhailidis, D. P.en
dc.contributor.authorElisaf, M.en
dc.date.accessioned2015-11-24T16:56:45Z
dc.date.available2015-11-24T16:56:45Z
dc.identifier.issn0300-7995-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/10480
dc.rightsDefault Licence-
dc.subjectdense high-density lipoprotein (hdl)en
dc.subjectezetimibeen
dc.subjectlipoprotein subfiractionsen
dc.subjectlow-density lipoprotein cholesterol (ldl-c)en
dc.subjectsmall, dense ldlen
dc.subjectlow-density-lipoproteinen
dc.subjectcholesterol absorption inhibitoren
dc.subjectprimary hypercholesterolemiaen
dc.subjectarterial-wallen
dc.subjectmyocardial-infarctionen
dc.subjectmixed hyperlipidemiaen
dc.subjectclinical-practiceen
dc.subjectapolipoprotein-ben
dc.subjectldl-cholesterolen
dc.subjectconsensus-panelen
dc.titleEffect of ezetimibe monotherapy on the concentration of lipoprotein subfractions in patients with primary dyslipidaemiaen
heal.abstractBackground: Recent studies suggest that the distribution of lipoprotein subfractions is an independent predictor of vascular events. Therefore, we evaluated the effect of ezetimibe (a selective cholesterol transport inhibitor) on the concentrations of lipoprotein subfractions in patients with primary dyslipidaemia. Materials and methods: Patients (n = 50) with primary dyslipidaemias were recruited. The concentrations of the individual lipoprotein subfractions were measured using the Lipoprint system at baseline and after 16 weeks of treatment. Results: Ezetimibe reduced total, low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (HDL-C values as well as apolipoprotein B concentrations. Subfractionation of apolipoprotein B-containing lipoproteins showed that the reduction in LDL-C values was due to a fall in the concentrations of all LDL subfractions. However, a more pronounced trend towards a decrease in the concentrations of dense LDL subfractions was observed. Patients with triglyceride values >1.7 mmol/L had significantly greater reductions in the concentrations of small, dense LDL particles compared with those with normal triglyceride levels (49 vs. 19%, respectively; p < 0.05). Ezetimibe decreased the concentrations of HDL-C mainly due to a fall in the concentration of dense HDL subfractions. Conclusion: Ezetimibe can favourably affect the distribution of LDL subfractions, especially in patients with elevated triglyceride values. Further studies are needed to clarify the significance of the ezetimibe-induced reduction in the concentrations of dense HDL particles.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDoi 10.1185/030079907x188062-
heal.identifier.secondary<Go to ISI>://000248757500025-
heal.identifier.secondaryhttp://informahealthcare.com/doi/abs/10.1185/030079907X188062-
heal.journalNameCurrent Medical Research and Opinionen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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