The PON1 M55L gene polymorphism is associated with reduced HDL-associated PAF-AH activity

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dc.contributor.authorKakafika, A. I.en
dc.contributor.authorXenofontos, S.en
dc.contributor.authorTsimihodimos, V.en
dc.contributor.authorTambaki, A. P.en
dc.contributor.authorLourida, E. S.en
dc.contributor.authorKalaitzidis, R.en
dc.contributor.authorCariolou, M. A.en
dc.contributor.authorElisaf, M.en
dc.contributor.authorTselepis, A. D.en
dc.date.accessioned2015-11-24T16:50:58Z
dc.date.available2015-11-24T16:50:58Z
dc.identifier.issn0022-2275-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9668
dc.rightsDefault Licence-
dc.subjecthigh density lipoproteinen
dc.subjectplatelet-activating factor acetylhydrolaseen
dc.subjectparaoxonase-1en
dc.subjectpon1 polymorphismsen
dc.subjectplatelet-activating factor acetyllrydrolase polymorphismsen
dc.subjectplatelet-activating-factoren
dc.subjecthigh-density-lipoproteinen
dc.subjectcoronary-heart-diseaseen
dc.subjectindependent risk-factoren
dc.subjectfactor-acetylhydrolaseen
dc.subjectoxidative modificationen
dc.subjectmissense mutationen
dc.subjectparaoxonase geneen
dc.subjectartery diseaseen
dc.subjecthuman-plasmaen
dc.titleThe PON1 M55L gene polymorphism is associated with reduced HDL-associated PAF-AH activityen
heal.abstractThe platelet-activating factor acetylhydrolase activity associated with high density lipoprotein (HDL-PAF-AH) may substantially contribute to the antioxidant, antiinflammatory, and overall antiatherogenic effects of HDL. Two enzymes associated with HDL express PAF-AH catalytic activity, PAF-AH itself and paraoxonase-1 (PON1). The relative contribution of these enzymes in the expression of PAF-AH activity on HDL remains to be established. We investigated whether the PON1 polymorphisms (M55L and Q192R) or the PAF-AH polymorphism V379A could affect the PAF-AH activity associated with HDL in both normolipidemic and dyslipidemic (type IIA and IIB) populations. We show for the first time that the PON1 M55L polymorphism significantly affects the HDI-PAF-AH activity in all studied groups, the PON1 L55L individuals having lower enzyme activity compared to those having 1 M and 2 M alleles. No differences in the HDL content concerning the major apolipoprotein and lipid constituents were observed between individuals carrying the PON1 L55L and those with the M55M polymorphism. jlr Our results provide evidence that PON1 significantly contributes to the pool of HDL-PAF-AH activity in human plasma, and suggest that the low PAF-AH activity in HDL carrying the PON1 L alloenzyme may be an important factor contributing to the low efficiency of this HDL in protecting LDL against lipid peroxidation.-Kakafika, A. I., S. Xenofontos, V Tsimihodimos, A. P. Tambaki, E. S. Lourida, R. Kalaitzidis, M. A. Cariolou, M. Elisaf, and A. D. Tselepis. The PON1 M55L gene polymorphism is associated with reduced HDL-associated PAF-AH activity. J. Lipid Res. 2003.44:1919-1926.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1194/jlr.M300129-JLR200-
heal.identifier.secondary<Go to ISI>://000186043900012-
heal.identifier.secondaryhttp://www.jlr.org/content/44/10/1919.full.pdf-
heal.journalNameJournal of Lipid Researchen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2003-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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