Influenza virus H5N1 haemagglutinin(HA) T cell epitope conjugates:Design, Synthesis and Immunogenicity
| dc.contributor.author | Skarlas, Th., | en |
| dc.contributor.author | Zevgiti, S., | en |
| dc.contributor.author | Droebner, K., | en |
| dc.contributor.author | Panou-Pomonis, E., | en |
| dc.contributor.author | Planz, O., | en |
| dc.contributor.author | Sakarellos-Daitsiotis, M. | en |
| dc.date.accessioned | 2015-11-24T16:39:55Z | |
| dc.date.available | 2015-11-24T16:39:55Z | |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/8207 | |
| dc.rights | Default Licence | - |
| dc.subject | H5N1 | en |
| dc.subject | hemagglutinin (HA) | en |
| dc.subject | T-cell epitopes of HA | en |
| dc.subject | immunogenic SOC4-conjugates | en |
| dc.subject | protective immunity | en |
| dc.title | Influenza virus H5N1 haemagglutinin(HA) T cell epitope conjugates:Design, Synthesis and Immunogenicity | en |
| heal.abstract | The influenza virus, major surface glycoprotein hemagglutinin (HA) is one of the principal targets for the development of protective immunity. Aiming at contributing to the development of a vaccine that remains the first choice for prophylactic intervention, a reconstituted model of HA, mimicking its antigenic properties was designed, synthesized and tested in mice for the induction of protective immunity. Four helper T lymphocyte [HTL (T1, T3, T7 and T8)] and four cytotoxic lymphocyte [CTL (T2, T4, T5 and T6)] epitopes were coupled in two copies each to an artificial carrier, SOC4, which was formed by the repeating tripeptide Lys-Aib-Gly. The helical conformation of the SOC4-conjugates preserves the initial topology of the attached epitopes, which is critical for their immunogenic properties. Survival of immunized animals, ranged from 30 to 50%, points out the induction of protective immunity by using the SOC4-conjugates. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1002/psc.1320 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/doi/10.1002/psc.1320/abstract | - |
| heal.journalName | J. Pept. Sci. | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2011 | - |
| heal.publisher | Wiley | en |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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