Paclitaxel, cisplatin, leucovorin, and continuous infusion fluorouracil followed by concomitant chemoradiotherapy for locally advanced squamous cell carcinoma of the head and neck - A Hellenic cooperative oncology group phase II study

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dc.contributor.authorFountzilas, G.en
dc.contributor.authorTolis, C.en
dc.contributor.authorKalogera-Fountzila, A.en
dc.contributor.authorMisailidou, D.en
dc.contributor.authorTsekeris, P.en
dc.contributor.authorKarina, M.en
dc.contributor.authorNikolaou, A.en
dc.contributor.authorSamantas, E.en
dc.contributor.authorMakatsoris, T.en
dc.contributor.authorAthanassiou, E.en
dc.contributor.authorSkarlos, D.en
dc.contributor.authorBamias, A.en
dc.contributor.authorZamboglou, N.en
dc.contributor.authorEconomopoulos, T.en
dc.contributor.authorKaranastassi, S.en
dc.contributor.authorPavlidis, N.en
dc.contributor.authorDaniilidis, J.en
dc.date.accessioned2015-11-24T18:39:16Z
dc.date.available2015-11-24T18:39:16Z
dc.identifier.issn1357-0560-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/17413
dc.rightsDefault Licence-
dc.subjectpaclitaxelen
dc.subjectchemotherapyen
dc.subjecthead and neck canceren
dc.subjectinduction chemotherapyen
dc.subjectradiation-therapyen
dc.subjectrandomized-trialen
dc.subjectorgan preservationen
dc.subjectweekly carboplatinen
dc.subjectcanceren
dc.subjectradiotherapyen
dc.subjectsurvivalen
dc.subjectradiochemotherapyen
dc.subjectoxaliplatinen
dc.titlePaclitaxel, cisplatin, leucovorin, and continuous infusion fluorouracil followed by concomitant chemoradiotherapy for locally advanced squamous cell carcinoma of the head and neck - A Hellenic cooperative oncology group phase II studyen
heal.abstractThe primary objective of this phase II study was to access the complete response (CR) rate to a new innovative induction regimen in patients with locally advanced head and neck cancer (LA-HNC). From October 2000 until October 2003 a total of 38 eligible patients (33 men and 5 women) entered the study. The large majority of them presented with a performance status of 0-1 and with clinical stage IV disease. Treatment consisted of three cycles of induction chemotherapy (IC) with paclitaxel 175 mg/m(2) in a 3-h infusion on d 1, leucovorin (LV) 200 mg/m(2) over 20 min immediately followed by FU 400 mg/m(2) bolus and then 600 mg/m(2) as a 24-h continuous infusion on d 1 and 2 and a cisplatin 75 mg/m(2) over 1-h infusion on d 2 every 3 wk. This was then followed by radiation (70 Gy) and weekly cisplatin 40 mg/m(2). After the completion of IC, 6/38 (16%) patients had CR. The CR rate was increased to 66% post-concomitant chemoradiotherapy (CCRT). Neutropenia (37.5%), pain (62%), nausea/vomiting (21%), and alopecia (79%) were the most frequent side effects during IC. The most pronounced toxicities during chemoradiotherapy were stomatitis (62.5%) and xerostomia (53%). Median time to progression was 11.0 mo and median survival 16.7 mo. One- and 2-yr survival rates were 73% and 38%, respectively. In conclusion, this novel induction regimen is active, is well tolerated, and can be successfully followed by CCRT with weekly cisplatin. CCRT should remain standard treatment for patients with LA-HNC. Novel induction combinations, such as that reported in the present study, should be evaluated in combination with CCRT only in the context of clinical trials.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDoi 10.1385/Mo:22:3:269-
heal.identifier.secondary<Go to ISI>://000231533600007-
heal.identifier.secondaryhttp://link.springer.com/content/pdf/10.1385%2FMO%3A22%3A3%3A269.pdf-
heal.journalNameMedical Oncologyen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2005-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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