Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene

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dc.contributor.authorWeydert, A.en
dc.contributor.authorDaubas, P.en
dc.contributor.authorLazaridis, I.en
dc.contributor.authorBarton, P.en
dc.contributor.authorGarner, I.en
dc.contributor.authorLeader, D. P.en
dc.contributor.authorBonhomme, F.en
dc.contributor.authorCatalan, J.en
dc.contributor.authorSimon, D.en
dc.contributor.authorGuenet, J. L.en
dc.contributor.authoret al.,en
dc.date.accessioned2015-11-24T19:15:01Z
dc.date.available2015-11-24T19:15:01Z
dc.identifier.issn0027-8424-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21435
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectBase Sequenceen
dc.subjectChromosome Mappingen
dc.subjectCloning, Molecularen
dc.subjectCrosses, Geneticen
dc.subjectDNA/geneticsen
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectMice/*geneticsen
dc.subjectMusclesen
dc.subjectMyocardiumen
dc.subjectMyosins/*geneticsen
dc.subjectPolymorphism, Geneticen
dc.subjectSpecies Specificityen
dc.titleGenes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain geneen
heal.abstractMyosin heavy chain (MHC) genes are expressed as several distinct isoforms in a tissue- and stage-specific manner; three skeletal muscle MHC isoforms appear sequentially during development. We have isolated cDNA clones, identified by RNA blot hybridization and by nucleotide sequence determination as coding for portions of the embryonic (pMHC2.2), perinatal (pMHC16.2A), and alpha(V1) cardiac (pMHC141 and pMHC101) MHC isoforms. These four probes and the adult skeletal MHC probe (pMHC32) have been used on Southern blots of genomic DNA to detect restriction fragment length polymorphisms defining the alleles for these genes in mouse species Mus musculus and Mus spretus. In this way, we followed the segregation of skeletal and cardiac MHC genes in 42 offspring resulting from an interspecies backcross. We found that the embryonic, perinatal, and adult skeletal MHC genes are clustered on chromosome 11 near the locus nude, the skeletal and cardiac MHC genes do not cosegregate, and the alpha(V1) cardiac MHC gene is located on chromosome 14 close to Np-1. This result is in contrast to that for other contractile protein genes such as the alkali myosin light chain and the actin multigene families, which are dispersed in the genome.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/3864153-
heal.journalNameProc Natl Acad Sci U S Aen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1985-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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