Association of serum and follicular fluid SHBG levels and SHBG (TAAAA)n polymorphism with follicle size in women undergoing ovarian stimulation

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dc.contributor.authorHatzi, E.en
dc.contributor.authorBouba, I.en
dc.contributor.authorGalidi, A.en
dc.contributor.authorLazaros, L.en
dc.contributor.authorXita, N.en
dc.contributor.authorSakaloglou, P.en
dc.contributor.authorKolios, G.en
dc.contributor.authorBairaktari, E.en
dc.contributor.authorKaponis, A.en
dc.contributor.authorZikopoulos, K.en
dc.contributor.authorTsatsoulis, A.en
dc.contributor.authorGeorgiou, I.en
dc.date.accessioned2015-11-24T19:34:40Z
dc.date.available2015-11-24T19:34:40Z
dc.identifier.issn1473-0766-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23642
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAllelesen
dc.subjectFemaleen
dc.subjectFertilization in Vitroen
dc.subjectFollicular Fluid/*chemistryen
dc.subjectGenotypeen
dc.subjectHumansen
dc.subjectInfertility/therapyen
dc.subjectOvarian Follicle/*anatomy & histologyen
dc.subject*Ovulation Inductionen
dc.subjectPolymorphism, Genetic/*geneticsen
dc.subjectPregnancyen
dc.subjectSex Hormone-Binding Globulin/*analysis/*geneticsen
dc.subjectSperm Injections, Intracytoplasmicen
dc.titleAssociation of serum and follicular fluid SHBG levels and SHBG (TAAAA)n polymorphism with follicle size in women undergoing ovarian stimulationen
heal.abstractOBJECTIVE: Sex hormone-binding globulin (SHBG) is the main transport protein of sex steroids. Recently, it has been found to be produced by granulosa lutein cells, suggesting a local role of SHBG in the ovary. The aim of this study was to investigate whether serum and follicular fluid SHBG levels and SHBG (TAAAA)(n) polymorphism are related to follicle size and pregnancy rate in women undergoing in vitro fertilisation. METHODS: The study population consisted of 154 women with tubal and/or male-factor infertility undergoing IVF/ICSI and follicular fluid with oocytes from small (diameter </=12 mm) and large (diameter >/=18 mm) follicles were studied. Genotyping of SHBG (TAAAA)(n) polymorphism was performed in peripheral blood samples. Serum and follicular fluids were used for hormones determination. RESULTS: Women with short allele genotypes (with less than 8 TAAAA repeats) had higher number of small follicles compared to women with long allele genotypes (5.6 +/- 3.9 vs. 3.5 +/- 3.2 small follicles, p < 0.003). Follicular fluid SHBG levels correlated positively with serum SHBG levels (p < 0.001) and with the total number of follicles (p < 0.02). Furthermore, small follicles had higher follicular fluid SHBG concentration compared to large follicles (102.9 +/- 35.0 nmol/l vs. 85.85 +/- 34.88 nmol/l, p < 0.028). CONCLUSION: SHBG levels and the SHBG (TAAAA)(n) polymorphism are associated with follicle size.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.3109/09513590.2010.493961-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/20540673-
heal.identifier.secondaryhttp://informahealthcare.com/doi/abs/10.3109/09513590.2010.493961-
heal.journalNameGynecol Endocrinolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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