Synthesis, crystal structure, spectral properties and cytotoxic activity of platinum(II) complexes of 2-acetyl pyridine and pyridine-2-carbaldehyde N(4)-ethyl-thiosemicarbazones
| dc.contributor.author | Kovala-Demertzi, D. | en |
| dc.contributor.author | Yadav, P. N. | en |
| dc.contributor.author | Demertzis, M. A. | en |
| dc.contributor.author | Coluccia, M. | en |
| dc.date.accessioned | 2015-11-24T16:49:33Z | |
| dc.date.available | 2015-11-24T16:49:33Z | |
| dc.identifier.issn | 0162-0134 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9502 | |
| dc.rights | Default Licence | - |
| dc.subject | platinum(ii) complexes | en |
| dc.subject | thiosemicarbazonato complexes | en |
| dc.subject | crystal structure | en |
| dc.subject | spectroscopic studies | en |
| dc.subject | cytotoxic activity | en |
| dc.subject | p-isopropylbenzaldehyde thiosemicarbazone | en |
| dc.subject | palladium(ii) complexes | en |
| dc.subject | biological-activity | en |
| dc.subject | antitumor-activity | en |
| dc.subject | in-vitro | en |
| dc.subject | 3-hexamethyleneiminylthiosemicarbazones | en |
| dc.subject | compound | en |
| dc.subject | binding | en |
| dc.subject | pd(ii) | en |
| dc.subject | cells | en |
| dc.title | Synthesis, crystal structure, spectral properties and cytotoxic activity of platinum(II) complexes of 2-acetyl pyridine and pyridine-2-carbaldehyde N(4)-ethyl-thiosemicarbazones | en |
| heal.abstract | The reactions of Na2PtCl4 with pyridine-2-carbaldehyde and 2-acetyl pyridine N(4)-ethyl-thiosemicarbazones, HFo4Et and HAc4Et respectively, afforded the complexes [Pt(Fo4Et)Cl], [Pt(HFo4Et)(2)]Cl-2, [Pt(Fo4Et)(2)] and [Pt(Ac4Et)Cl], [Pt(HAc4Et)(2)]Cl-2. 2H(2)O, [Pt(Ac4Et)(2)]. The new complexes have been characterized by elemental analyses and spectroscopic studies. The crystal structure of the complex [Pt(Ac4Et)Cl] has been solved. The anion of Ac4E coordinates in a planar conformation to the central platinum(II) through the pyridyl N, azomethine Nand thiolato S atoms. Intermolecular hydrogen, non-hydrogen bonds, pi-pi and weak Pt-pi contacts lead to aggregation and a supramolecular assembly. The cytotoxic activity for the platinum( II) complexes in comparison to that of cisplatin and thiosemicarbazones was evaluated in a pair of cisplatin-sensitive and -resistant ovarian cancer cell lines A2780 and A2780/Cp8. The platinum(II) complexes showed a cytotoxic potency in a very low micromolar range and were found able to overcome the cisplatin resistance of A2780/Cp8 cells. (C) 2000 Elsevier Science Inc. All rights reserved. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | <Go to ISI>://000087513500012 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0162013400000635/1-s2.0-S0162013400000635-main.pdf?_tid=7062e8206e5c7a50ecaa3e13477e0703&acdnat=1333028916_9032c64411c47a8fa24fc7851cea1bbe | - |
| heal.journalName | J Inorg Biochem | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2000 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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