Multiple anchoring of myelopeptides on sequential oligopeptide carriers (SOCn): synthesis, conformation and studies in human leukemia cells

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dc.contributor.authorKeramisanou, D.en
dc.contributor.authorTsikaris, V.en
dc.contributor.authorSakarellos-Daitsiotis, M.en
dc.contributor.authorSakarellos, C.en
dc.contributor.authorMikhailova, A. A.en
dc.contributor.authorStrelkov, L. A.en
dc.date.accessioned2015-11-24T16:42:24Z
dc.date.available2015-11-24T16:42:24Z
dc.identifier.issn1397-002X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8545
dc.rightsDefault Licence-
dc.subjectcell differentiation process and myelopeptidesen
dc.subjectmyelopeptidesen
dc.subjectmyelopeptides conjugated to the sequential oligopeptide carriersen
dc.subjectnuclear magnetic resonance of myelopeptidesen
dc.subjectglycopeptide dendrimersen
dc.subjectantigenic peptidesen
dc.subjectepitope analogsen
dc.subjectdifferentiationen
dc.subjectautoantigenen
dc.subjectantibodyen
dc.titleMultiple anchoring of myelopeptides on sequential oligopeptide carriers (SOCn): synthesis, conformation and studies in human leukemia cellsen
heal.abstractMyelopeptides, MP-6 (Val-Asp-Pro-Pro) and MP-4 (Phe-Arg-Pro-Arg-Ile-Met-Thr-Pro), induce metabolic changes in human leukemia cells, HL-60, characteristic of the differentiation process, which should be regarded as a promising therapeutic approach in cancer and related diseases. With the aim to optimize the differentiation effect of MPs, they were coupled to the Lys-(NH2)-H-epsilon groups of a sequential oligopeptide carrier Ac-(Lys-Aib-Gly)(4), SOC4, and the constructs obtained were studied. The rigid 3(10) secondary structure of the carrier is preserved even after linkage of the MPs, which also maintain their initial conformations without interacting either with each other or with the carrier, as demonstrated by H-1 nuclear magnetic resonance (NMR) spectroscopy. It is concluded that the carrier accommodates the presentation of MPs, thus improving their differentiation effect on human leukemia cells.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000177951100005-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1034/j.1399-3011.2002.21017.x/asset/j.1399-3011.2002.21017.x.pdf?v=1&t=h0e0m5jy&s=14f49c3551a6ae422028497b0047a2619ad0bf52-
heal.journalNameJournal of Peptide Researchen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2002-
heal.publisherBlackwell Munksgaarden
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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