Effects of atorvastatin on red-blood cell Na(+)/Li(+) countertransport in hyperlipidemic patients with and without hypertension

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dc.contributor.authorKosmidou, M. S.en
dc.contributor.authorHatzitolios, A. I.en
dc.contributor.authorAdamidou, A.en
dc.contributor.authorGiannopoulos, S.en
dc.contributor.authorRaikos, N.en
dc.contributor.authorParharidis, G.en
dc.contributor.authorMilionis, H. J.en
dc.date.accessioned2015-11-24T19:21:48Z
dc.date.available2015-11-24T19:21:48Z
dc.identifier.issn0895-7061-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22123
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAnticholesteremic Agents/*pharmacology/therapeutic useen
dc.subjectBiological Transport/drug effectsen
dc.subjectBlood Pressure/drug effectsen
dc.subjectCholesterol/blooden
dc.subjectDose-Response Relationship, Drugen
dc.subjectErythrocytes/*metabolism/pathologyen
dc.subjectFemaleen
dc.subjectHeptanoic Acids/*pharmacology/therapeutic useen
dc.subjectHumansen
dc.subjectHyperlipidemias/drug therapy/*metabolism/pathologyen
dc.subjectHypertension/*metabolism/pathologyen
dc.subjectInsulin Resistanceen
dc.subjectLinear Modelsen
dc.subjectLithium/*metabolismen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPyrroles/*pharmacology/therapeutic useen
dc.subjectSodium/*metabolismen
dc.subjectTriglycerides/blooden
dc.titleEffects of atorvastatin on red-blood cell Na(+)/Li(+) countertransport in hyperlipidemic patients with and without hypertensionen
heal.abstractBACKGROUND: To explore the effect of short-term cholesterol-lowering treatment with atorvastatin on erythrocyte sodium-lithium countertransport (Na(+)/Li(+) CT) activity. METHODS: Group A consisted of 30 patients (14 men) with mild essential hypertension (systolic blood pressure (SBP), 140-159 mm Hg and/or diastolic BP, 90-99 mm Hg) and primary hypercholesterolemia low-density lipoprotein (LDL) cholesterol >4.1 mmol/l and triglycerides (TG) <2.8 mmol/l), group B of 30 normotensive patients (16 men) with primary hypercholesterolemia, while 37 (18 men) healthy volunteers comprised the control group. After a 6-week dietary lead-in, all eligible patients were prescribed 20 mg/day of atorvastatin. Anthropometric data, blood-pressure (BP) measurements and determinations of lipid, non-lipid metabolic parameters (including homeostasis model assessment index, (HOMA-IR)) and erythrocyte Na(+)/Li(+) CT activity were collected at baseline and after 12 weeks of treatment. RESULTS: At baseline Na(+)/Li(+) CT activity was significantly higher in group A and B compared with the control group and correlated directly with obesity indices, systolic and diastolic BP, total cholesterol, LDL-cholesterol, TG, apolipoprotein B (apoB), HOMA-IR, uric acid and inversely with high-density lipoprotein (HDL)-cholesterol and apoA1. Systolic and diastolic BP levels, HOMA-IR and Na(+)/Li(+) CT activity were significantly decreased after atorvastatin treatment in both patient groups. The reduction in Na(+)/Li(+) CT activity correlated with baseline Na(+)/Li(+) CT activity and the changes in HOMA-IR values. CONCLUSIONS: Short-term treatment with atorvastatin for patients with hypercholesterolemia, and with or without essential hypertension, is associated with a significant reduction in the erythrocyte Na(+)/Li(+) CT activity, BP levels and insulin resistance independent of concomitant changes in lipid parameters.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1038/ajh.2007.61-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18202666-
heal.journalNameAm J Hypertensen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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