Prognostic significance of UBE2C mRNA expression in high-risk early breast cancer. A Hellenic Cooperative Oncology Group (HeCOG) Study

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dc.contributor.authorPsyrri, A.en
dc.contributor.authorKalogeras, K. T.en
dc.contributor.authorKronenwett, R.en
dc.contributor.authorWirtz, R. M.en
dc.contributor.authorBatistatou, A.en
dc.contributor.authorBournakis, E.en
dc.contributor.authorTimotheadou, E.en
dc.contributor.authorGogas, H.en
dc.contributor.authorAravantinos, G.en
dc.contributor.authorChristodoulou, C.en
dc.contributor.authorMakatsoris, T.en
dc.contributor.authorLinardou, H.en
dc.contributor.authorPectasides, D.en
dc.contributor.authorPavlidis, N.en
dc.contributor.authorEconomopoulos, T.en
dc.contributor.authorFountzilas, G.en
dc.date.accessioned2015-11-24T18:56:13Z
dc.date.available2015-11-24T18:56:13Z
dc.identifier.issn1569-8041-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19003
dc.rightsDefault Licence-
dc.titlePrognostic significance of UBE2C mRNA expression in high-risk early breast cancer. A Hellenic Cooperative Oncology Group (HeCOG) Studyen
heal.abstractBACKGROUND: The ubiquitin-proteasome system (UPS) plays a pivotal role in tumorigenesis. Components of the UPS have recently been implicated in breast cancer progression. In the present study, we sought to explore the prognostic and/or predictive significance of UBE2C messenger RNA (mRNA) expression on disease-free survival (DFS) and overall survival (OS) in high-risk operable breast cancer patients. METHODS: Five hundred and ninety-five high-risk breast cancer patients were treated in a two-arm trial evaluating postoperative, dose-dense sequential chemotherapy with epirubicin followed by CMF (cyclophosphamide, methotrexate and 5-fluorouracil) with or without paclitaxel (Taxol). RNA was extracted from 313 formalin-fixed primary tumor tissue samples followed by one-step quantitative RT-PCR for assessment of mRNA expression of UBE2C. RESULTS: High UBE2C mRNA expression was associated with poor DFS (Wald's P = 0.003) and OS (Wald's P = 0.005). High tumor grade, as well as high Ki67 protein expression, was more frequent in the high-expression group of UBE2C. Results of the Cox multivariate regression analysis revealed that high UBE2C mRNA expression remained an independent adverse prognostic factor for relapse (P = 0.037) and death (P = 0.05). CONCLUSIONS: High UBE2C mRNA expression was found to be of adverse prognostic significance in high-risk breast cancer patients. These findings need to be validated in larger cohorts.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1093/annonc/mdr527-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/22056852-
heal.identifier.secondaryhttp://annonc.oxfordjournals.org/content/early/2012/01/15/annonc.mdr527.full.pdf-
heal.journalNameAnn Oncolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2012-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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