The natural course of primary Sjogren's syndrome (a clinical study)
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Pavlidis, N. A.
Drosos, A. A.
Galanopoulos, V.
Siamopoulos, C.
Tsianos, E. B.
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peer-reviewed
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Ter Arkh
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In this work the authors analyzed the clinical course and diagnostic procedures of 104 patients with primary Sjogren's syndrome (pSS): 57 patients diagnosed and followed-up at Ioannina University and 47 similar patients treated at the National Institute of Health (USA). Both studies have shown that pSS is predominantly a female disease with a latent period of 6-8 yrs from the time of the first symptom to the time of final diagnosis. Although the syndrome begins almost exclusively with glandular manifestations (xerostomia, xerophthalmia or parotid gland enlargement), in a respectable percentage of patients it eventually progresses to extraglandular involvement. pSS can be potentially complicated by benign (pseudolymphoma) or malignant (lymphoma) lymphoproliferative disorders.
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Keywords
Adult, Female, Greece, Humans, Hypertrophy, Lymphoma/etiology, Middle Aged, Parotid Gland/pathology, Raynaud Disease/diagnosis, Sjogren's Syndrome/complications/diagnosis/*ethnology, United States, Xerophthalmia/diagnosis/ethnology, Xerostomia/diagnosis/ethnology
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http://www.ncbi.nlm.nih.gov/pubmed/3394101
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ru
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής