Expression of vascular endothelial growth factor and its receptor, KDR/Flk-1, in soft tissue sarcomas

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dc.contributor.authorPakos, E. E.en
dc.contributor.authorGoussia, A. C.en
dc.contributor.authorTsekeris, P. G.en
dc.contributor.authorPapachristou, D. J.en
dc.contributor.authorStefanou, D.en
dc.contributor.authorAgnantis, N. J.en
dc.date.accessioned2015-11-24T18:28:44Z
dc.date.available2015-11-24T18:28:44Z
dc.identifier.issn0250-7005-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/16177
dc.rightsDefault Licence-
dc.subjectsoft tissue sarcomaen
dc.subjectvegfen
dc.subjectflk-1en
dc.subjectmvden
dc.subjectangiogenesisen
dc.subjectfactor vegf overexpressionen
dc.subjectmicrovessel densityen
dc.subjecttumor angiogenesisen
dc.subjectprognostic-factoren
dc.subjecttyrosine kinaseen
dc.subjectcanceren
dc.subjectcorrelateen
dc.subjectmetastasisen
dc.subjectcarcinomaen
dc.subjectsurvivalen
dc.titleExpression of vascular endothelial growth factor and its receptor, KDR/Flk-1, in soft tissue sarcomasen
heal.abstractThe aim of the present study was to evaluate the association of vascular endothelial growth factor (VEGF) and its receptor, KDR/Flk-1, with tumor grade, microvessel density (MVD) and clinical outcome in patients with soft tissue sarcomas (STSs). Tissue specimens of 28 patients with STSs were analyzed immunohistochemically using specific monoclonal antibodies. Tissue samples were obtained prior to any treatment. Half of the STSs exhibited strong expression of VEGF that was associated statistically significantly with high tumor grade. Strong expression of KDR/Flk-1 was detected in only 2 sarcomas. No association was demonstrated between VEGF and KDR/FIk-1 expression. MVD was significantly associated with tumor grade and was higher in sarcomas with strong VEGF expression. Limited data on clinical outcome precluded solid analyses for an association with disease progression. This study provides further evidence on the role of VEGF and MVD in tumor aggressiveness in STSs.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000231077600064-
heal.identifier.secondaryhttp://ar.iiarjournals.org/content/25/5/3591.full.pdf-
heal.journalNameAnticancer Resen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2005-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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