Age as a limiting factor for successful sperm retrieval in patients with nonmosaic Klinefelter's syndrome

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dc.contributor.authorOkada, H.en
dc.contributor.authorGoda, K.en
dc.contributor.authorYamamoto, Y.en
dc.contributor.authorSofikitis, N.en
dc.contributor.authorMiyagawa, I.en
dc.contributor.authorMio, Y.en
dc.contributor.authorKoshida, M.en
dc.contributor.authorHorie, S.en
dc.date.accessioned2015-11-24T19:37:19Z
dc.date.available2015-11-24T19:37:19Z
dc.identifier.issn1556-5653-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24012
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectBiopsy/methodsen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectKlinefelter Syndrome/*complications/genetics/pathologyen
dc.subjectMaleen
dc.subjectMedical Recordsen
dc.subjectMicrodissection/methodsen
dc.subjectMosaicismen
dc.subjectOligospermia/etiology/pathology/*therapyen
dc.subject*Paternal Ageen
dc.subjectPregnancyen
dc.subject*Pregnancy Outcomeen
dc.subjectSperm Injections, Intracytoplasmicen
dc.subjectSpermatozoa/*cytologyen
dc.subjectTestis/cytologyen
dc.titleAge as a limiting factor for successful sperm retrieval in patients with nonmosaic Klinefelter's syndromeen
heal.abstractOBJECTIVE: To determine factors affecting successful sperm retrieval by testicular sperm extraction in patients with nonmosaic Klinefelter's syndrome. DESIGN: Medical record analysis for nonmosaic Klinefelter's syndrome patients who underwent testicular sperm extraction. SETTING: Three university-based tertiary centers. PATIENT(S): Fifty-one patients with nonobstructive azoospermia related to nonmosaic Klinefelter's syndrome. INTERVENTION(S): Testicular sperm extraction. MAIN OUTCOME MEASURE(S): Correlation of patient characteristics; serum concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone (T); as well as testicular volume with success in testicular sperm extraction. RESULT(S): We succeeded in obtaining spermatozoa in 26 patients and failed in 25. Levels of LH, FSH, and T and testicular volume did not differ between patient groups defined by success and failure. Median ages for successful and failed testicular sperm extraction were 31 and 38 years, respectively (statistically significant difference). When we analyzed success rates of testicular sperm extraction between two patient groups (<35 and > or =35 years old), the percentage of successful recovery of spermatozoa decreased after the age of 35 years (statistically significant difference). CONCLUSION(S): Testicular sperm extraction should be recommended before the critical age of 35 years.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.fertnstert.2005.05.053-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16359961-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0015028205029407/1-s2.0-S0015028205029407-main.pdf?_tid=509d26b92edb3f32e261ac7b42ba0ca8&acdnat=1333716594_0712af683897b1a047487e22e41d7802-
heal.journalNameFertil Sterilen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2005-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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