Growth factors, adiponectin, leptin and body mass index in pre-pubertal children born large for gestational age
| dc.contributor.author | Challa, A. S. | en |
| dc.contributor.author | Evagelidou, E. N. | en |
| dc.contributor.author | Giapros, V. I. | en |
| dc.contributor.author | Cholevas, V. I. | en |
| dc.contributor.author | Andronikou, S. K. | en |
| dc.date.accessioned | 2015-11-24T19:14:29Z | |
| dc.date.available | 2015-11-24T19:14:29Z | |
| dc.identifier.issn | 1720-8386 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21323 | |
| dc.rights | Default Licence | - |
| dc.title | Growth factors, adiponectin, leptin and body mass index in pre-pubertal children born large for gestational age | en |
| heal.abstract | OBJECTIVE: To examine whether the IGF axis in pre-pubertal children born large for gestational age (LGA) differs from that of those born appropriate for gestational age (AGA). RESEARCH DESIGN AND METHODS: The study population consisted of 98 non-obese children aged 5.5-8 yr, of whom 37 were LGA, with birth weight (BW) > 90th percentile, and 61 AGA. The LGA children were subdivided into two subgroups, with BW 90th-97th percentile (no.=24) and BW > 97th percentile (no.=13), respectively. Total and free IGF-I, their binding proteins 1 and 3 (IGFBP-1 and IGFBP-3), leptin, adiponectin, fasting glucose (GF) and insulin (IF) were measured, and the homeostasis model assessment for insulin resistance (HOMA-IR index) was determined. RESULTS: IGF-I, free IGF-I and IGFBP-1 were similar in both groups. Both LGA subgroups had lower IGFBP-3 levels than the AGA group (2.34 +/- 0.61 and 2.70 +/- 0.90, respectively, vs 3.92 +/- 1.1 mug/ml, p < 0.01). Adiponectin was higher in the 90th-97th percentile LGA subgroup than the AGA group (p<0.01). GF and IF were higher in the LGA group (86.5 +/- 5.6 mg/dl, p < 0.01, and 5.84 +/- 2.13 muU/ml, respectively, p < 0.05) than in the AGA group (82.6 +/- 7.7 mg/dl and 4.62 +/- 1.9 muU/ml, respectively), as was the HOMA-IR index (1.27 +/- 0.60 vs 0.94 +/- 0.43, p < 0.01). These three parameters were also found higher in the >97th percentile LGA subgroup. CONCLUSION: The IGF axis was not different in pre-pubertal children born LGA or AGA, with the exception of IGFBP-3, which was lower in the LGA children. In LGA pre-pubertal children the severity of intrauterine overgrowth was associated with the insulin resistance indices. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.3275/7138 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/20585203 | - |
| heal.journalName | J Endocrinol Invest | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2011 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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