Bone minerals in beta-thalassemia minor

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dc.contributor.authorKalef-Ezra, J.en
dc.contributor.authorChalla, A.en
dc.contributor.authorChaliasos, N.en
dc.contributor.authorHatzikonstantinou, I.en
dc.contributor.authorPapaefstathiou, I.en
dc.contributor.authorCholevas, V.en
dc.contributor.authorGlaros, D.en
dc.contributor.authorLapatsanis, P.en
dc.date.accessioned2015-11-24T19:32:26Z
dc.date.available2015-11-24T19:32:26Z
dc.identifier.issn8756-3282-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23413
dc.rightsDefault Licence-
dc.subjectAbsorptiometry, Photonen
dc.subjectAdulten
dc.subjectAging/metabolismen
dc.subjectBiological Markers/blood/urineen
dc.subjectBone Density/*physiologyen
dc.subjectBone Diseases, Metabolic/*physiopathologyen
dc.subjectFemaleen
dc.subjectForearmen
dc.subjectHanden
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNeutron Activation Analysisen
dc.subjectPhosphorus/metabolismen
dc.subjectPremenopauseen
dc.subjectSex Factorsen
dc.subjectbeta-Thalassemia/genetics/*physiopathologyen
dc.titleBone minerals in beta-thalassemia minoren
heal.abstractHomozygous beta-thalassemia is a severe hereditary disorder associated with osteopenia. Recently it was suggested that thalassemia minor may be a risk factor for osteoporosis. The purpose of the present study was to investigate this suggestion. Bone mineral status was assessed in 22 premenopausal women and 21 men with beta-thalassemia minor. In vivo neutron activation analysis was applied to measure hand-bone phosphorus (HBP), single-photon absorptiometry to measure forearm bone mineral content (BMC), and dual-energy X-ray absorptiometry to measure spinal bone mineral density (BMD). Comparison of the HBP, BMC, and BMD values with those of sex- and age-matched healthy subjects without the beta-thalassemia trait failed to indicate a statistically significant difference for either sex group. Concerning the biochemical markers of bone metabolism that were studied (serum calcium, phosphate, alkaline phosphatase, osteocalcin, and parathyroid hormone, and 3-h fasting urine calcium-to-urine creatinine ratio) no difference was observed between the study subjects and matched controls. In conclusion, the present study showed that subjects with beta-thalassemia minor are not at risk for osteoporosis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/7669442-
heal.identifier.secondaryhttp://ac.els-cdn.com/875632829500117V/1-s2.0-875632829500117V-main.pdf?_tid=7980efe205d6f391150b095e45d30b6e&acdnat=1336114460_28b3b01794b569cdc652805b4445256f-
heal.journalNameBoneen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1995-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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