Platinum(II) complexes with 2-acetyl pyridine thiosemicarbazone - Synthesis, crystal structure, spectral properties, antimicrobial and antitumour activity
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Ημερομηνία
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Inorg Biochem
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
An interesting series of new platinum complexes has been synthesized by the reaction of Na(2)ptCl(4) with 2-acetyl pyridine thiosemicarbazone, HAcTsc. The new complexes, [Pt(AcTsc)CI], [Pt(HAcTsc),]Cl-2 and [Pt(AcTsc)(2)], have been characterized by elemental analyses and spectroscopic studies. The crystal structure of the complex [Pt(AcTsc)CI] has been solved by single-crystal X-ray diffraction. The anion of HAcTsc coordinates in a planar conformation to the central platinum(II) through the pyridyl N, azomethine N and thiolato S atoms. Double intermolecular hydrogen bonds (NH-CI), pi-pi and weak Pt-Pt and Pt-pi contacts lead to aggregation and to a two-dimensional supramolecular assembly. The antibacterial and antifungal effect of the novel platinum(II) complexes and the related palladium(fl) complexes, [Pd(AcTsc)CI], [d(HAcTsc),]Cl, and [Pd(AcTsc),], were studied in vitro. The complexes were found to have a completely lethal effect on Gram+ bacteria, while the same complexes showed no bactericidal effect on Gram- bacteria. Additionally, the complexes [Pt(AcTsc),] and [Pd(AcTsc),] showed effective antifungal activity towards yeast. Among these compounds [33], the most effective in inducing antitumour and cytogenetic effects are the complexes [Pt(AcTsc)(2)] and [Pd(AcTsc)(2)] while the rest, display marginal cytogenetic and antitumour effects. (C) 2001 Elsevier Science BY All rights reserved.
Περιγραφή
Λέξεις-κλειδιά
platinum(ii) complex, thiosemicarbazonato complex, crystal structure, spectroscopic study, antibacterial, antifungal, antineoplastic activity, p-isopropylbenzaldehyde thiosemicarbazone, palladium(ii) complexes, cytotoxic activity, biological-activity, DNA-binding, in-vitro, 3-hexamethyleneiminylthiosemicarbazones, copper(ii), compound, ligand
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000171350800003
http://ac.els-cdn.com/S0162013401002240/1-s2.0-S0162013401002240-main.pdf?_tid=8f6117edb92ecc8694c53d3a0f7de56b&acdnat=1333028678_cc18c53575f1ea29de46d28f0a904100
http://ac.els-cdn.com/S0162013401002240/1-s2.0-S0162013401002240-main.pdf?_tid=8f6117edb92ecc8694c53d3a0f7de56b&acdnat=1333028678_cc18c53575f1ea29de46d28f0a904100
Γλώσσα
en
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Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας