Metabolic adaptation to feeding and fasting during lactation in humans
| dc.contributor.author | Tigas, S. | en |
| dc.contributor.author | Sunehag, A. | en |
| dc.contributor.author | Haymond, M. W. | en |
| dc.date.accessioned | 2015-11-24T19:04:39Z | |
| dc.date.available | 2015-11-24T19:04:39Z | |
| dc.identifier.issn | 0021-972X | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20080 | |
| dc.rights | Default Licence | - |
| dc.subject | 3-Hydroxybutyric Acid/blood | en |
| dc.subject | Adaptation, Physiological | en |
| dc.subject | Adult | en |
| dc.subject | Blood Glucose/analysis | en |
| dc.subject | C-Peptide/blood | en |
| dc.subject | Carbon Isotopes | en |
| dc.subject | *Eating | en |
| dc.subject | *Fasting | en |
| dc.subject | Fatty Acids/blood | en |
| dc.subject | Female | en |
| dc.subject | Glucagon/blood | en |
| dc.subject | Glucose/administration & dosage/metabolism | en |
| dc.subject | Glycerol/metabolism | en |
| dc.subject | Humans | en |
| dc.subject | Insulin/blood | en |
| dc.subject | *Lactation | en |
| dc.subject | Lactic Acid/biosynthesis/blood | en |
| dc.subject | Milk, Human/metabolism | en |
| dc.subject | Postpartum Period | en |
| dc.subject | Time Factors | en |
| dc.title | Metabolic adaptation to feeding and fasting during lactation in humans | en |
| heal.abstract | The aim of these studies was to determine the metabolic adaptation to fasting and feeding during lactation. Normal lactating (L) and nonlactating (NL) women (n = 6 each) were studied using infusions of [U-13C]glucose and [2-13C]glycerol during: 1) a 24-h fast, and 2) ingestion of Sustacal (protocol 1). In addition, 8 L and 6 NL women were studied during infusion of [6,6-2H2]glucose and ingestion of a glucose meal containing [1-13C]glucose (protocol 2). Protocol 1: Glucose production rate (GPR) during fasting was 33% higher in the L women (12.5 +/- 1.0 vs. 9.4 +/- 0.5 micromol x kg(-1) x min(-1); P < 0.03). Fractional gluconeogenesis (GNG), GNG rate, glucose, lactate, beta- hydroxybutyrate, FFA, insulin, and C-peptide were similar in both groups during feeding and fasting, but glycogenolysis was 50% higher in fasting L women. Protocol 2: Although GPR was slightly increased in the L group (L, 1.8 +/- 0.2 micromol x kg(-1) x min(-1); NL, 1.2 +/- 0.2 micromol x kg(-1) x min(-1); P < 0.04), no other differences were observed in splanchnic and systemic metabolism of ingested glucose between L and NL women. Insulin concentrations were lower in L women compared with controls (L, 15 +/- 3 microU/ml; NL, 28 +/- 6 microU/ml; P = 0.05). In conclusion, the increased glucose demands of lactation are met by increased GPR as a result of increased glycogenolysis but not GNG or by increased use of FFA. During feeding, lactating women handle oral carbohydrates normally but have increased insulin sensitivity. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/11788664 | - |
| heal.identifier.secondary | http://jcem.endojournals.org/content/87/1/302.full.pdf | - |
| heal.journalName | J Clin Endocrinol Metab | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2002 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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