Chronic skeletal muscle ischemia in rats decreases the inducibility of ventricular tachyarrhythmias after myocardial infarction

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dc.contributor.authorManiotis, C.en
dc.contributor.authorTsalikakis, D. G.en
dc.contributor.authorTzallas, A. T.en
dc.contributor.authorVarnavas, V.en
dc.contributor.authorKontaras, K.en
dc.contributor.authorGlava, C.en
dc.contributor.authorBaltogiannis, G. G.en
dc.contributor.authorPapalois, A.en
dc.contributor.authorKolettis, T. M.en
dc.contributor.authorKyriakides, Z. S.en
dc.date.accessioned2015-11-24T19:30:33Z
dc.date.available2015-11-24T19:30:33Z
dc.identifier.issn1791-7549-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23121
dc.rightsDefault Licence-
dc.subjectAction Potentialsen
dc.subjectAnimalsen
dc.subjectElectrocardiographyen
dc.subjectHeart Rateen
dc.subjectHindlimb/*blood supplyen
dc.subject*Ischemic Preconditioningen
dc.subjectMuscle, Skeletal/*blood supplyen
dc.subjectMyocardial Infarction/*complications/pathologyen
dc.subjectMyocardial Reperfusion Injury/*complicationsen
dc.subjectMyocardium/pathologyen
dc.subjectRatsen
dc.subjectRats, Wistaren
dc.subjectTachycardia, Ventricular/etiology/*prevention & controlen
dc.titleChronic skeletal muscle ischemia in rats decreases the inducibility of ventricular tachyarrhythmias after myocardial infarctionen
heal.abstractBACKGROUND: Chronic hind-limb ischemia confers cytoprotection after coronary occlusion, but it is unclear whether it ameliorates substrate formation for ventricular tachyarrhythmias (VTs). MATERIALS AND METHODS: Chronic hind-limb ischemia was generated by femoral artery excision in 50 rats, while 25 animals were sham-operated. Left coronary artery ligation was performed after 3 weeks and infarct size was measured 24 hours thereafter. The inducibility of VTs was assessed by programmed electrical stimulation (PES) 4 weeks post-ligation. A score was assigned, based on protocol stage and tachyarrhythmia duration. Monophasic action potentials (MAP) were recorded prior to and 4 weeks after ligation. RESULTS: The infarct size was smaller (p=0.000079) in the ischemic rats (25.7+/-2.1%) than in the controls (41.7+/-2.2%), accompanied by a lower (p=0.029) arrhythmia score (1.05+/-0.38 versus 2.70+/-0.68, respectively). The action potential duration (APD) was shorter (p<0.05) in the ischemic rats prior to ligation and remained stable after 4 weeks. CONCLUSION: Chronic hind limb ischemia limits infarct size and decreases inducible ventricular tachyarrhythmias.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21753134-
heal.journalNameIn Vivoen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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