Proportion of excision and cervical healing after large loop excision of the transformation zone for cervical intraepithelial neoplasia

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dc.contributor.authorFounta, C.en
dc.contributor.authorArbyn, M.en
dc.contributor.authorValasoulis, G.en
dc.contributor.authorKyrgiou, M.en
dc.contributor.authorTsili, A.en
dc.contributor.authorMartin-Hirsch, P.en
dc.contributor.authorDalkalitsis, N.en
dc.contributor.authorKarakitsos, P.en
dc.contributor.authorKassanos, D.en
dc.contributor.authorPrendiville, W.en
dc.contributor.authorLoufopoulos, A.en
dc.contributor.authorParaskevaidis, E.en
dc.date.accessioned2015-11-24T18:56:01Z
dc.date.available2015-11-24T18:56:01Z
dc.identifier.issn1471-0528-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18970
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectCervical Intraepithelial Neoplasia/pathology/*surgeryen
dc.subjectCervix Uteri/*physiology/surgeryen
dc.subjectElectrosurgery/*methodsen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMagnetic Resonance Imagingen
dc.subjectOrgan Sizeen
dc.subjectPregnancyen
dc.subjectPregnancy Complications, Neoplastic/*prevention & controlen
dc.subjectProspective Studiesen
dc.subjectRegeneration/*physiologyen
dc.subjectRisk Factorsen
dc.subjectUterine Cervical Neoplasms/pathology/*surgeryen
dc.subjectWound Healingen
dc.subjectYoung Adulten
dc.titleProportion of excision and cervical healing after large loop excision of the transformation zone for cervical intraepithelial neoplasiaen
heal.abstractOBJECTIVE: To determine how the proportion of the cervical volume excised affects cervical regeneration. DESIGN: Prospective observational study. SETTING: University Hospital. POPULATION: Women planning to undergo excisional treatment for cervical intraepithelial neoplasia who wish to have future pregnancies. METHODS: The cervical volume (and dimensions) is calculated with magnetic resonance imaging (MRI) before treatment. The volume (and dimensions) of the cone is assessed before fixation by a volumetric tube and a ruler; the percentage (%) of excision is computed. Cervical regeneration is estimated by repeat MRI at 6 months. Main outcome MEASURES: Cervical regeneration in relation to proportion of excision. Statistical analysis was performed by box plots and analysis of variance. RESULTS: A total of 48 women have been recruited; 29 have completed 6 months follow up. Both the total cervical volume (from MRI) before treatment and the volume of the excised/ablated cone varied substantially. The estimated proportion of excision varied significantly between 4% and 39% (median 11%). Multivariate linear regression revealed that the proportional deficit at 6 months post-treatment was determined mainly by the proportion of the excised volume. CONCLUSIONS: Careful assessment of risks and benefits of treatment is essential when deciding to treat women who wish to have future pregnancies. Assessment of the proportion of the cervical volume and length excised might identify those that need further surveillance during future pregnancy.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1111/j.1471-0528.2010.02709.x-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/20840527-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1471-0528.2010.02709.x/asset/j.1471-0528.2010.02709.x.pdf?v=1&t=h0p6rhn0&s=a57884f669ff90e56e01e8ec3585885c2b6bbdae-
heal.journalNameBJOGen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2010-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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