Appearance of thymosin alpha 1 in supernatants of monocytes incubated with prothymosin alpha

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dc.contributor.authorFrillingos, S.en
dc.contributor.authorSeferiadis, K.en
dc.contributor.authorPapanastasiou, M.en
dc.contributor.authorBaxevanis, C. N.en
dc.contributor.authorFrangou-Lazaridis, M.en
dc.contributor.authorEconomou, M.en
dc.contributor.authorPapamichail, M.en
dc.contributor.authorTsolas, O.en
dc.date.accessioned2015-11-24T19:35:46Z
dc.date.available2015-11-24T19:35:46Z
dc.identifier.issn0003-9861-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23741
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectCells, Cultureden
dc.subjectHumansen
dc.subjectKineticsen
dc.subjectLymphocyte Culture Test, Mixeden
dc.subjectMonocytes/*metabolismen
dc.subjectProtein Precursors/genetics/isolation & purification/*metabolismen
dc.subjectRNA, Messenger/genetics/metabolismen
dc.subjectSwineen
dc.subjectT-Lymphocytes/metabolismen
dc.subjectThymosin/*analogs & derivatives/genetics/isolation & purification/metabolismen
dc.subjectThymus Gland/metabolismen
dc.subjectTime Factorsen
dc.titleAppearance of thymosin alpha 1 in supernatants of monocytes incubated with prothymosin alphaen
heal.abstractProthymosin alpha, a polypeptide of 109 to 111 amino acid residues, contains the entire thymosin alpha 1 sequence (residues 1-28) at its amino terminal. Human peripheral blood monocytes incubated with prothymosin alpha release thymosin alpha 1 in the culture supernatants. In addition total RNA is found to increase. The production of thymosin alpha 1 involves de novo protein synthesis as shown by the kinetics of this release and its inhibition by actinomycin D and cycloheximide. Thymosin alpha 1 release, possibly in association with HLA-DR, stimulates the proliferation of the T cell population.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/1534980-
heal.identifier.secondaryhttp://ac.els-cdn.com/000398619290570M/1-s2.0-000398619290570M-main.pdf?_tid=8518ce52c969308d2f779cf660076cf9&acdnat=1337335260_e49498ea7fceb020e29265a9a35a4580-
heal.journalNameArch Biochem Biophysen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1992-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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