Immunohistochemical evaluation of cathepsin D expression in colorectal tumours: a correlation with extracellular matrix components, p53, pRb, bcl-2, c-erbB-2, EGFR and proliferation indices

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dc.contributor.authorIoachim, E. E.en
dc.contributor.authorGoussia, A. C.en
dc.contributor.authorMachera, M.en
dc.contributor.authorTsianos, E. V.en
dc.contributor.authorKappas, A. M.en
dc.contributor.authorAgnantis, N. J.en
dc.date.accessioned2015-11-24T19:12:00Z
dc.date.available2015-11-24T19:12:00Z
dc.identifier.issn0250-7005-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20999
dc.rightsDefault Licence-
dc.subjectAdenocarcinoma/chemistry/*enzymology/pathologyen
dc.subjectAdenoma/chemistry/pathologyen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectCathepsin D/*analysisen
dc.subjectCell Divisionen
dc.subjectCollagen/analysisen
dc.subjectColorectal Neoplasms/chemistry/*enzymology/pathologyen
dc.subjectDisease Progressionen
dc.subjectExtracellular Matrix Proteins/analysisen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImmunoenzyme Techniquesen
dc.subjectKi-67 Antigen/analysisen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNeoplasm Proteins/*analysisen
dc.subjectProliferating Cell Nuclear Antigen/analysisen
dc.subjectProtein Isoforms/analysisen
dc.subjectProto-Oncogene Proteins c-bcl-2/analysisen
dc.subjectReceptor, Epidermal Growth Factor/analysisen
dc.subjectReceptor, erbB-2/analysisen
dc.subjectRetinoblastoma Protein/analysisen
dc.subjectStromal Cells/chemistryen
dc.subjectTumor Suppressor Protein p53/analysisen
dc.titleImmunohistochemical evaluation of cathepsin D expression in colorectal tumours: a correlation with extracellular matrix components, p53, pRb, bcl-2, c-erbB-2, EGFR and proliferation indicesen
heal.abstractThe immunohistochemical Cathepsin D (CD) expression of tumour and stromal cells was investigated in a series of 93 human colorectal adenocarcinomas and 22 adenomas with the intention to evaluate its prognostic significance and its contribution in the metastatic potential of colorectal cancer. CD expression was correlated with the expression of extracellular matrix components (collagen type IV, laminin and fibronectin), p53 protein, pRb, bcl-2, c-erbB-2, EGFR, proliferation indices (Ki-67, PCNA) as well as with other conventional clinicopathological features. CD expression (> 10% of positive tumour cells) was observed in 60.2% of carcinomas and in 72.7% of adenomas. Stromal CD expression was detected in all cases. A statistically significant positive correlation between neoplastic cells CD and stromal cells CD (SCCD) was observed in both carcinomas and adenomas. Cancer cells CD (CCCD) was positively correlated with collagen type IV and pRb expression as well as with PCNA score. In carcinomas, SCCD expression was statistically correlated with p53 protein and pRb expression and a trend for correlation with PCNA score was found. These data suggest that Cathepsin D of cancer and stromal cells, especially in combination with other markers, may provide more information about the biological behaviour of colorectal cancer.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10470163-
heal.journalNameAnticancer Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1999-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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