Vitamin D receptor gene polymorphisms in multiple sclerosis patients in northwest Greece

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dc.contributor.authorSioka, C.en
dc.contributor.authorPapakonstantinou, S.en
dc.contributor.authorMarkoula, S.en
dc.contributor.authorGkartziou, F.en
dc.contributor.authorGeorgiou, A.en
dc.contributor.authorGeorgiou, I.en
dc.contributor.authorPelidou, S. H.en
dc.contributor.authorKyritsis, A. P.en
dc.contributor.authorFotopoulos, A.en
dc.date.accessioned2015-11-24T19:41:14Z
dc.date.available2015-11-24T19:41:14Z
dc.identifier.issn1477-5751-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24461
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectFemaleen
dc.subjectGenotypeen
dc.subjectGreeceen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMultiple Sclerosis/*geneticsen
dc.subject*Polymorphism, Single Nucleotideen
dc.subjectReceptors, Calcitriol/*geneticsen
dc.subjectRegression Analysisen
dc.subjectTaq Polymerase/metabolismen
dc.titleVitamin D receptor gene polymorphisms in multiple sclerosis patients in northwest Greeceen
heal.abstractBACKGROUND: Polymorphisms of the vitamin D receptor (VDR) gene have been linked to both multiple sclerosis (MS) and osteoporosis. We examined the frequency of the Taq-I and Bsm-I polymorphisms of the vitamin D receptor (VDR) gene in 69 patients with MS and 81 age and sex-matched healthy individuals. Genotyping of Taq-I (rs731236) and Bsm-I (rs1544410) was performed using TaqMan SNP Genotyping Assay. All patients and controls had determination of body mass index (BMI), bone mineral density (BMD) and smoking history. RESULTS: The mean age of patients was 39 +/- 10.5 years compared to 38.7 +/- 10.7 years of the controls (p = 0.86), the BMI was 24.8 +/- 4.2 kg/m2 compared to 25.7 +/- 4.8 kg/m2 of the controls (p = 0.23), the BMD in the lumbar spine 0.981 +/- 0.15 compared to 1.025 +/- 013 of the controls (p = 0.06) and the total hip BMD was 0.875 +/- 0.14 compared to 0.969 +/- 0.12 of the controls (p < 0.001). There were no differences of the Taq-I (TT, CT, CC) and Bsm-I genotypes (GG, GA, AA) and allelic frequencies between MS and control individuals. Multivariate analysis also failed to show any association of the Taq-I and Bsm-I polymorphisms and MS or sex, BMI, BMD and smoking history. CONCLUSIONS: This study suggests that the Taq-I and Bsm-I polymorphisms of the VDR gene are not associated with MS risk, BMI or BMD in the Greek population studied.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1186/1477-5751-10-3-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21545713-
heal.identifier.secondaryhttp://www.jnrbm.com/content/pdf/1477-5751-10-3.pdf-
heal.journalNameJ Negat Results Biomeden
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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