Red cell phosphate metabolism in full-term neonates
Φόρτωση...
Ημερομηνία
Συγγραφείς
Challa, A.
Chaliasos, N.
Liossis, G.
Palaskas, C.
Staphylakis, C.
Lapatsanis, P.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Helvetica Paediatrica Acta
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
The effects of hypoxia and feeding on red cell inorganic phosphate (Pi) concentrations were studied in neonates. Although hypoxia caused a rise in extracellular Pi, the intracellular concentration of this ion did not change in comparison to control infants of the same age (first 24 h). As a result of these changes, the distribution of phosphate ions across the erythrocyte membrane was significantly lower in the hypoxic infants than in the controls. In the hypoxic infants, adenosine triphosphate (ATP) levels in the red cells were found significantly lower than in controls, while the 2,3-diphosphoglycerate (2,3-DPG) levels were raised. In breast-fed 2 or 3-day-old neonates, both plasma and red cell Pi were found to be increased but to different degrees, affecting therefore the molar Pi distribution, which was lower than in the controls of the first day. In these infants, ATP was lower and 2,3-DPG higher than in the controls of the first day of life. These findings suggest that intracellular phosphate metabolism in neonates does not follow extracellular phosphate changes. Further investigation is needed to elucidate the controlling factors.
Περιγραφή
Λέξεις-κλειδιά
2,3-Diphosphoglycerate, Adenosine Triphosphate/blood, Asphyxia Neonatorum/*blood, Calcium/blood, Diphosphoglyceric Acids/blood, Erythrocytes/*metabolism, Hematocrit, Humans, Infant, Newborn, Phosphates/*blood
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/3843235
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής