Oxidative Stress Based-Biomarkers In Oral Carcinogenesis: How Far Have We Gone?
| dc.contributor.author | Hanafi, R. | en |
| dc.contributor.author | Anestopoulos, I. | en |
| dc.contributor.author | Voulgaridou, G. P. | en |
| dc.contributor.author | Franco, R. | en |
| dc.contributor.author | Georgakilas, A. G. | en |
| dc.contributor.author | Ziech, D. | en |
| dc.contributor.author | Malamou-Mitsi, V. | en |
| dc.contributor.author | Pappa, A. | en |
| dc.contributor.author | Panayiotidis, M. I. | en |
| dc.date.accessioned | 2015-11-24T19:00:22Z | |
| dc.date.available | 2015-11-24T19:00:22Z | |
| dc.identifier.issn | 1875-5666 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19518 | |
| dc.rights | Default Licence | - |
| dc.title | Oxidative Stress Based-Biomarkers In Oral Carcinogenesis: How Far Have We Gone? | en |
| heal.abstract | Oral cancer accounts for 2-3% of all malignancies and according to the World Health Organization (WHO) is the fifth most common cancer worldwide. On the other hand, "oxidative stress" implies a cellular state whereby reactive oxygen species (ROS) production exceeds its metabolism resulting in excessive ROS accumulation and overwhelmed cellular defenses. Such a state has been shown to be involved in the multistage process of human carcinogenesis (including oral cancer) via many different mechanisms. Amongst them are ROS-induced oxidative modifications on major cellular macromolecules like DNA, proteins and lipids with the resulting byproducts being involved in the pathophysiology of human oral malignant and pre-malignant lesions. Throughout this manuscript, we review the current state of knowledge on the role of these oxidative-modified cellular byproducts in serving as reliable biomarkers for oral cancer detection, prognosis and diagnosis. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/22292437 | - |
| heal.journalName | Curr Mol Med | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2012 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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