Effect of perioperative immuno-enhanced enteral nutrition on inflammatory response, nutritional status, and outcomes in head and neck cancer patients undergoing major surgery

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dc.contributor.authorFelekis, D.en
dc.contributor.authorEleftheriadou, A.en
dc.contributor.authorPapadakos, G.en
dc.contributor.authorBosinakou, I.en
dc.contributor.authorFerekidou, E.en
dc.contributor.authorKandiloros, D.en
dc.contributor.authorKatsaragakis, S.en
dc.contributor.authorCharalabopoulos, K.en
dc.contributor.authorManolopoulos, L.en
dc.date.accessioned2015-11-24T19:22:39Z
dc.date.available2015-11-24T19:22:39Z
dc.identifier.issn1532-7914-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22180
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectArginine/therapeutic useen
dc.subjectBiological Markers/blooden
dc.subjectCarcinoma, Squamous Cell/complications/surgeryen
dc.subjectDouble-Blind Methoden
dc.subject*Enteral Nutritionen
dc.subjectFatty Acids, Omega-3/therapeutic useen
dc.subjectFemaleen
dc.subject*Food, Formulateden
dc.subjectHead and Neck Neoplasms/complications/*surgeryen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMalnutrition/complicationsen
dc.subjectMiddle Ageden
dc.subject*Nutritional Statusen
dc.subject*Perioperative Careen
dc.subjectPostoperative Complications/blood/immunology/*prevention & controlen
dc.subjectRNA/therapeutic useen
dc.subjectTreatment Outcomeen
dc.titleEffect of perioperative immuno-enhanced enteral nutrition on inflammatory response, nutritional status, and outcomes in head and neck cancer patients undergoing major surgeryen
heal.abstractAdministration of immuno-enhanced nutritional support may decrease postoperative morbidity, mortality, and infectious complications in cancer patients. The aim of this study was to verify that perioperative enteral diet, enriched with the nutrients arginine, ribonucleic acid (RNA), and omega-3 fatty acids improves outcomes of head and neck cancer patients undergoing major surgery. Forty patients with squamous cell carcinoma of the head and neck were studied. Group 1 received no preoperative nutritional support, whereas Group 2 received an oral formula with nutrients arginine, RNA, and omega-3 fatty acids. After surgery, Group 1 received a standard enteral formula, whereas Group 2 received an enriched enteral formula. Albumin (g/dl), prealbumin, fibrinogen, CRP, Il-6, and TNFa were measured 5 days before and 8 days after surgery. No statistically significant difference was observed for all the evaluated markers between postoperative and preoperative levels for both groups. The rate of complications was significantly reduced in the total number of patients receiving immunonutrition and in the particular subgroup of well-nourished patients receiving an immuno-enhanced diet. Perioperative enteral immuno-enhanced feeding in head and neck cancer patients undergoing major surgery may influence the postoperative outcomes by reducing the frequency rate of infections and wound complications.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1080/01635581.2010.494336-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21058198-
heal.identifier.secondaryhttp://www.tandfonline.com/doi/pdf/10.1080/01635581.2010.494336-
heal.journalNameNutr Canceren
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2010-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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