Epstein-Barr virus (EBV) genomes and EBV-encoded latent membrane protein (LMP) in pulmonary lymphomas occurring in nonimmunocompromised patients

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dc.contributor.authorSabourin, J. C.en
dc.contributor.authorKanavaros, P.en
dc.contributor.authorBriere, J.en
dc.contributor.authorLescs, M. C.en
dc.contributor.authorPetrella, T.en
dc.contributor.authorZafrani, E. S.en
dc.contributor.authorGaulard, P.en
dc.date.accessioned2015-11-24T19:18:44Z
dc.date.available2015-11-24T19:18:44Z
dc.identifier.issn0147-5185-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21894
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAntigens, Viral/*analysisen
dc.subjectHerpesvirus 4, Human/*isolation & purificationen
dc.subjectHumansen
dc.subjectImmunocompetenceen
dc.subjectImmunocompromised Hosten
dc.subjectImmunophenotypingen
dc.subjectIn Situ Hybridizationen
dc.subjectLung Neoplasms/*immunology/microbiology/pathologyen
dc.subjectLymphoma, B-Cell/immunology/microbiology/pathologyen
dc.subjectLymphoma, Non-Hodgkin/*immunology/microbiology/pathologyen
dc.subjectLymphoma, T-Cell/immunology/microbiology/pathologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectRNA, Viral/analysisen
dc.subjectTumor Virus Infections/*immunology/pathologyen
dc.subjectViral Matrix Proteins/*analysisen
dc.titleEpstein-Barr virus (EBV) genomes and EBV-encoded latent membrane protein (LMP) in pulmonary lymphomas occurring in nonimmunocompromised patientsen
heal.abstractRecently, in situ hybridization (ISH) techniques have shown that Epstein-Barr virus (EBV) could be detected in tumor cells of most angiocentric T-cell non-Hodgkin's lymphomas (NHL). These studies included only a few cases of T-NHL of the lung and pulmonary B-NHL and have not been investigated. Furthermore, the expression of the EBV-encoded latent membrane protein (LMP), which is known for its oncogenic properties, has not been reported. Twelve pulmonary NHL (six angiocentric T-NHL and six B-NHL) arising in nonimmunocompromised patients were examined for the presence of EBV-EBER mRNAs and LMP with ISH and immunohistochemistry, respectively. Four cases of pulmonary lymphomas arising in immunocompromised patients were also included in the study for comparison (one T-NHL in a patient under immunosuppressive treatment and three B-NHL in AIDS patients). EBV-RNA and LMP were detected in tumor cells in two of six nonimmunocompromised angiocentric T-NHL and in the four immunocompromised NHL. The six nonimmunocompromised B-NHL were EBV negative. These results suggest that EBV is associated with some angiocentric pulmonary T-NHL arising in patients without overt immunodeficiency whereas it is absent in such patients with B-NHL. The presence of the transforming EBV-encoded LMP in tumor cells suggests that EBV may be involved in the pathogenesis of some pulmonary T-NHL.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8396858-
heal.journalNameAm J Surg Patholen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1993-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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