Effects of intranasal salmon calcitonin in juvenile idiopathic arthritis: an observational study
| dc.contributor.author | Siamopoulou, A. | en |
| dc.contributor.author | Challa, A. | en |
| dc.contributor.author | Kapoglou, P. | en |
| dc.contributor.author | Cholevas, V. | en |
| dc.contributor.author | Mavridis, A. K. | en |
| dc.contributor.author | Lapatsanis, P. D. | en |
| dc.date.accessioned | 2015-11-24T19:21:04Z | |
| dc.date.available | 2015-11-24T19:21:04Z | |
| dc.identifier.issn | 0171-967X | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22081 | |
| dc.rights | Default Licence | - |
| dc.subject | Absorptiometry, Photon | en |
| dc.subject | Administration, Intranasal | en |
| dc.subject | Adolescent | en |
| dc.subject | Alkaline Phosphatase/blood | en |
| dc.subject | Arthritis, Juvenile Rheumatoid/*drug therapy/metabolism/physiopathology | en |
| dc.subject | Biological Markers/blood/urine | en |
| dc.subject | Bone Density/drug effects | en |
| dc.subject | Bone Resorption/drug therapy/metabolism | en |
| dc.subject | Calcitonin/administration & dosage/*therapeutic use | en |
| dc.subject | Calcium/metabolism/therapeutic use | en |
| dc.subject | Dietary Supplements | en |
| dc.subject | Humans | en |
| dc.subject | Joints/physiopathology | en |
| dc.subject | Lumbar Vertebrae/metabolism/radiography | en |
| dc.subject | Osteocalcin/blood | en |
| dc.subject | Severity of Illness Index | en |
| dc.subject | Treatment Outcome | en |
| dc.title | Effects of intranasal salmon calcitonin in juvenile idiopathic arthritis: an observational study | en |
| heal.abstract | The aim of this study was to follow the changes in bone mineral density (BMD) and biochemical markers of bone turnover in 10 children (7.5-17.5 years of age) with severe juvenile idiopathic arthritis (JIA), during a 3-year therapy with salmon calcitonin (100 IU/day 2 months on and 2 off for a year and 200 IU/day for 2 years) and calcium (500 mg/day). All patients were functional classes III and IV and were measured at yearly intervals with a dual photon absorptiometer at the lumbar spine. The changes observed were 7.2-9.5% per year for BMD and 2.0-6.0% for volumetric bone mineral density (BMDvol). The bone resorption markers showed significant decreases after a year's treatment (Pyr/Cr from 175+/-15 to 108+/-15 nm/mm, P < 0.001, Pyr-D/Cr from 24.3+/-3.5 to 13.3+/-1.9 nm/mm, P < 0.05, and OHPr/Cr from 57.4+/-11 to 35.1+/-8.4 microg/mg) and smaller changes thereafter. No significant changes were observed in the bone formation markers of osteocalcin and alkaline phosphatase. Serum iPTH, the vitamin D metabolites, and calcium concentrations fluctuated within normal, while calcium excretion increased from 0.3+/-0.1 to 1.9+/-0.4 mg/kg/24 hours, P < 0.001. In conclusion, the present study, despite its limitations of not being placebo controlled, shows possible beneficial effects of intranasal calcitonin on bone resorption and pain relief in JIA patients. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/11685430 | - |
| heal.identifier.secondary | http://www.springerlink.com/content/ca9wn0nt10ju07qa/fulltext.pdf | - |
| heal.journalName | Calcif Tissue Int | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2001 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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