Structural and in vitro biological studies of organotin(IV) precursors; Selective inhibitory activity against human breast cancer cells, positive to estrogen receptors
| dc.contributor.author | V.Ξ™. Balas, C.N. Banti, N. Kourkoumelis, S.K. Hadjikakou, G.D Geromichalos, D. Sahpazidou, L. Male, M.B. Hursthouse, B. Bednarz, M. Kubicki, K. Charalabopoulos and | en |
| dc.contributor.author | N. Hadjiliadis | en |
| dc.date.accessioned | 2015-11-24T16:47:56Z | |
| dc.date.available | 2015-11-24T16:47:56Z | |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9259 | |
| dc.rights | Default Licence | - |
| dc.title | Structural and in vitro biological studies of organotin(IV) precursors; Selective inhibitory activity against human breast cancer cells, positive to estrogen receptors | en |
| heal.abstract | Crystals of Ph3SnCl (1) were grown from a methanol/acetonitrile solution. Compounds [Ph3SnOH]n (2) and [(Ph2Sn)4Cl2O2(OH)2] (3) were crystallized from diethyl ether/methanol/acetonitrile and hot acetone/water solutions respectively, of the white precipitation, formed by adding KOH to solutions of 1 and [Ph2SnCl2] in 1 : 1 and 1 : 2 molar ratios respectively. Complex 1 was characterized by X-ray crystallography. X-ray structure determination of compounds 2 and 3 confirmed the previously reported identities. The molecular structure of 1, reported here, is a new polymorphic form of the known one for Ph3SnCl. Four independent [Ph3SnCl] molecules constitute the crystal structure of 1. The moieties are packed in two pairs in a tail-to-tail arrangement. Complexes 1-3 were evaluated for their in vitro cytotoxic activity (cell viability) against human cancer cell lines: HeLa (human cervical), MCF-7 (breast, estrogen receptor (ER) positive), MDA-MB-231 (breast, ER negative), A549 (lung), Caki-1 (kidney carcinoma), 786-O (renal adenocarcinoma), K1 (thyroid carcinoma), and the normal human lung cell line MRC-5 (normal human fetal lung fibroblast cells) versus, the normal immortalized human mammary gland epithelial cell line MTSV17 with a sulforhodamine B (SRB) assay. The results show potent cytotoxic activity of the complexes against all cell lines used, which was superior to that of cisplatin (CDDP). Compounds 1-3 showed higher activity against breast cancer cells MCF-7 (ER positive) than against of MDA-MB-231 (ER negative). These findings prompted us to search for possible interaction of these complexes with other cellular elements of fundamental importance in cell proliferation. The influence of these complexes 1-3 upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX), as well as their binding affinity towards calf thymus-DNA, were kinetically and theoretically studied. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | http://dx.doi.org/10.1071/CH12448 | - |
| heal.identifier.secondary | http://www.publish.csiro.au/paper/CH12448.htm | - |
| heal.journalName | Australian Journal of Chemistry | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2012 | - |
| heal.publisher | CSIRO | en |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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