Propofol prevents lung injury following intestinal ischemia-reperfusion

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dc.contributor.authorVasileiou, I.en
dc.contributor.authorKalimeris, K.en
dc.contributor.authorNomikos, T.en
dc.contributor.authorXanthopoulou, M. N.en
dc.contributor.authorPerrea, D.en
dc.contributor.authorAgrogiannis, G.en
dc.contributor.authorNakos, G.en
dc.contributor.authorKostopanagiotou, G.en
dc.date.accessioned2015-11-24T18:56:02Z
dc.date.available2015-11-24T18:56:02Z
dc.identifier.issn1095-8673-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18971
dc.rightsDefault Licence-
dc.subjectAcute Lung Injury/metabolism/pathology/*prevention & controlen
dc.subjectAnesthetics, Intravenous/pharmacology/*therapeutic useen
dc.subjectAnimalsen
dc.subjectAntioxidants/pharmacology/therapeutic useen
dc.subjectBronchoalveolar Lavageen
dc.subjectIntestines/*blood supply/metabolism/pathologyen
dc.subjectLipid Peroxidation/drug effects/physiologyen
dc.subjectMaleen
dc.subjectModels, Animalen
dc.subjectOxidative Stress/drug effects/physiologyen
dc.subjectPhosphorus/metabolismen
dc.subjectPropofol/pharmacology/*therapeutic useen
dc.subjectRatsen
dc.subjectRats, Wistaren
dc.subjectReperfusion Injury/*complications/metabolismen
dc.subjectThiobarbituric Acid Reactive Substances/metabolismen
dc.titlePropofol prevents lung injury following intestinal ischemia-reperfusionen
heal.abstractBACKGROUND: The antioxidant properties of propofol have been shown to improve ischemia/reperfusion injury. We investigated whether anesthesia with propofol can ameliorate remote lung injury induced by intestinal ischemia-reperfusion (IIR). MATERIALS AND METHODS: Thirty male Wistar rats were randomly allocated in three groups (n = 10 each): animals in group Sham were anesthetized with ketamine and xylazine and then laparotomy and sham IIR followed. Animals in group IIR received ketamine and xylazine and were then subjected to clamping of the superior mesenteric artery for 45 min and reperfusion for 4 h. Group IIR+P received anesthesia with propofol and then IIR was induced, as in group IIR. Blood samples for blood gases and malondialdehyde measurements were drawn at the end of reperfusion. Bronchoalveolar lavage fluid (BALF) was obtained to measure cell counts, total protein, and phospholipids levels. RESULTS: Induction of IIR resulted in deteriorated oxygenation, acidemia, and inflammatory cells sequestration, along with increased BALF protein content and increased proportions of small surfactant aggregates. Anesthesia with propofol alleviated intestinal injury and efficiently prevented lipid oxidation. In group IIR+P inflammatory cell infiltration and pulmonary histologic changes were significantly limited. The increase in BALF total protein and the changes in surfactant aggregates were prevented, leading to normal systemic oxygenation. CONCLUSION: Using propofol to induce and maintain anesthesia efficiently prevented IIR-induced lung injury. Systemic antioxidant protection, improvement of intestinal injury, inhibition of the inflammatory response, and preservation of the alveolar-capillary permeability seem to be crucial mediating mechanisms for this simple and clinically relevant intervention.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.jss.2010.07.034-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/20855084-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0022480410006359/1-s2.0-S0022480410006359-main.pdf?_tid=7f10fd5e74e8ffebc7cff31d2c05664b&acdnat=1333609486_9b657a292ae20f3615a0cc5610163d98-
heal.journalNameJ Surg Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2012-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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