The impact of the hormonal milieu and stress-associated hypothalamic dopaminergic activation on the rapid compensatory adrenal growth in cycling female rats
| dc.contributor.author | Sfikakis, A. | en |
| dc.contributor.author | Pitychoutis, P. M. | en |
| dc.contributor.author | Antoniou, K. | en |
| dc.contributor.author | Bikas, N. | en |
| dc.contributor.author | Papadopoulou-Daifoti, Z. | en |
| dc.date.accessioned | 2015-11-24T19:41:05Z | |
| dc.date.available | 2015-11-24T19:41:05Z | |
| dc.identifier.issn | 1109-3099 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24441 | |
| dc.rights | Default Licence | - |
| dc.subject | 3,4-Dihydroxyphenylacetic Acid/pharmacology | en |
| dc.subject | Adrenal Glands/drug effects/*growth & development/physiopathology | en |
| dc.subject | Adrenalectomy/*rehabilitation/veterinary | en |
| dc.subject | Animals | en |
| dc.subject | Dopamine/*metabolism/pharmacology | en |
| dc.subject | Estrous Cycle/blood/drug effects/physiology | en |
| dc.subject | Female | en |
| dc.subject | Hormones/blood/*physiology | en |
| dc.subject | Hypothalamus/drug effects/metabolism/*physiopathology | en |
| dc.subject | Neurons/drug effects/metabolism/physiology | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Wistar | en |
| dc.subject | Stress, Psychological/blood/metabolism/*physiopathology | en |
| dc.subject | Time Factors | en |
| dc.title | The impact of the hormonal milieu and stress-associated hypothalamic dopaminergic activation on the rapid compensatory adrenal growth in cycling female rats | en |
| heal.abstract | OBJECTIVE: We sought to investigate the impact of emotional and surgical stress applied in two hormonally different estrous-cycle phases as well as the hypothalamic dopaminergic involvement on the rapid compensatory adrenal growth (CAG) and the individual adrenal growth (IAG) in rats. DESIGN: After surgery for left and sham adrenalectomy (Adx) carried out on either diestrus-2 (DE-2) or proestrus (PE), CAG and IAG were evaluated in PE or estrus (E), respectively. Hypothalamic dopaminergic activity was also assessed by measuring dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) levels in DE-2, PE and E in controls and in PE and E in sham and left adrenalectomized rats. All groups experienced similar chronic emotional stress assessed by the emotional reactivity score recorded during vaginal screening. RESULTS: In controls, DOPAC levels in DE-2 were higher than in PE and E. In PE, following surgery in DE-2, DOPAC levels and DOPAC/DA ratio were increased compared to PE controls; CAG was not significant, while negative correlations of IAG and CAG with DOPAC/DA ratio were observed. In E, CAG and IAG were significant, while dopaminergic activity was not increased compared to E controls. CONCLUSIONS: The significant CAG and IAG following left Adx in PE but not in DE-2 suggest a pronounced positive impact of the hormonal milieu on this process. The profound attenuation of CAG and IAG in PE suggests a negative effect of stress-associated dopaminergic activation. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/19121991 | - |
| heal.journalName | Hormones (Athens) | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2008 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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