Comparative effectiveness of medical interventions in adults versus children
| dc.contributor.author | Contopoulos-Ioannidis, D. G. | en |
| dc.contributor.author | Baltogianni, M. S. | en |
| dc.contributor.author | Ioannidis, J. P. | en |
| dc.date.accessioned | 2015-11-24T19:28:58Z | |
| dc.date.available | 2015-11-24T19:28:58Z | |
| dc.identifier.issn | 1097-6833 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22938 | |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Age Factors | en |
| dc.subject | Child | en |
| dc.subject | Comparative Effectiveness Research | en |
| dc.subject | Health Services/*utilization | en |
| dc.subject | Humans | en |
| dc.subject | *Intervention Studies | en |
| dc.subject | Meta-Analysis as Topic | en |
| dc.subject | Odds Ratio | en |
| dc.subject | Outcome Assessment (Health Care) | en |
| dc.subject | Randomized Controlled Trials as Topic | en |
| dc.subject | Research Design | en |
| dc.subject | Treatment Outcome | en |
| dc.title | Comparative effectiveness of medical interventions in adults versus children | en |
| heal.abstract | OBJECTIVE: To estimate the comparative effectiveness of medical interventions in adults versus children. STUDY DESIGN: We identified from the Cochrane Database of Systematic Reviews (Issue 1, 2007) meta-analyses with data on at least 1 adult and 1 pediatric randomized trial with binary primary efficacy outcome. For each meta-analysis, we calculated the summary odds ratio of the adult trials and the pediatric trials, respectively; the relative odds ratio (ROR) of the adult versus pediatric odds ratios per meta-analysis; and the summary ROR across all meta-analyses. ROR <1 means that the experimental intervention is more unfavorable in children than adults. RESULTS: Across 128 eligible meta-analyses (1051 adult and 343 pediatric trials), the summary ROR did not show a statistically significant difference between adults and children (0.96; 95% confidence intervals, 0.86 to 1.08). However, in all meta-analyses except for 1, the individual ROR's 95% confidence intervals could not exclude a relative difference in efficacy over 20%. In two-thirds, the relative difference in observed point estimates exceeded 50%. Nine statistically significant discrepancies were identified; 4 of them were also clinically important. CONCLUSIONS: Treatment effects are on average similar in adults and children, but available evidence leaves large uncertainty about their relative efficacy. Clinically important discrepancies may occur. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1016/j.jpeds.2010.02.011 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/20434730 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0022347610001216/1-s2.0-S0022347610001216-main.pdf?_tid=0566388665c78496f117829115288497&acdnat=1333363539_ecd96816a4fd3aae783d2d014f022a25 | - |
| heal.journalName | J Pediatr | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2010 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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