CTLA-4 gene polymorphisms and susceptibility to type 1 diabetes mellitus: a HuGE Review and meta-analysis
| dc.contributor.author | Kavvoura, F. K. | en |
| dc.contributor.author | Ioannidis, J. P. | en |
| dc.date.accessioned | 2015-11-24T19:26:02Z | |
| dc.date.available | 2015-11-24T19:26:02Z | |
| dc.identifier.issn | 0002-9262 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22684 | |
| dc.rights | Default Licence | - |
| dc.subject | Antigens, CD | en |
| dc.subject | Antigens, Differentiation/*genetics | en |
| dc.subject | Autoantibodies | en |
| dc.subject | CTLA-4 Antigen | en |
| dc.subject | Developed Countries | en |
| dc.subject | Diabetes Mellitus, Type 1/epidemiology/*genetics | en |
| dc.subject | Genetic Heterogeneity | en |
| dc.subject | Genetic Predisposition to Disease | en |
| dc.subject | Glutamate Decarboxylase/immunology | en |
| dc.subject | Humans | en |
| dc.subject | Isoenzymes/immunology | en |
| dc.subject | Microsatellite Repeats/genetics | en |
| dc.subject | *Polymorphism, Genetic | en |
| dc.title | CTLA-4 gene polymorphisms and susceptibility to type 1 diabetes mellitus: a HuGE Review and meta-analysis | en |
| heal.abstract | The authors performed a meta-analysis of 33 studies examining the association of type 1 diabetes mellitus with polymorphisms in the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) gene, including the A49G (29 comparisons), C(-318)T (three comparisons), and (AT)n microsatellite (six comparisons) polymorphisms. The studies included 5,637 cases of type 1 diabetes and 6,759 controls (4,775 and 5,829, respectively, for analysis of the A49G polymorphism). The random-effects odds ratio for the *G (Ala) allele versus the *A (Thr) allele was 1.45 (95% confidence interval (CI): 1.28, 1.65), with significant between-study heterogeneity (p < 0.001). The effect size tended to be higher in type 1 diabetes cases with age of onset <20 years (odds ratio (OR) = 1.61), and there was a significant association between the presence of glutamic acid decarboxylase-65 autoantibodies and the *G allele among type 1 diabetes cases (OR = 1.49). Larger studies showed more conservative results (p = 0.011). After exclusion of studies with fewer than 150 subjects and studies with significant deviation from Hardy-Weinberg equilibrium in the controls, the summary odds ratio was 1.40 (95% CI: 1.28, 1.54). Available data showed no strong association for the 106-base-pair allele of the microsatellite polymorphism (OR = 0.99, 95% CI: 0.64, 1.55) or the *T allele of the C(-318)T polymorphism (OR = 0.92, 95% CI: 0.45, 1.89). This meta-analysis demonstrates that the CTLA-4*G genotype is associated with type 1 diabetes. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1093/aje/kwi165 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/15961581 | - |
| heal.identifier.secondary | http://aje.oxfordjournals.org/content/162/1/3.full.pdf | - |
| heal.journalName | Am J Epidemiol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2005 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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