Anticancer and cytotoxic effects of a triorganotin compound with 2-mercapto-nicotinic acid in malignant cell lines and tumor bearing Wistar rats

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dc.contributor.authorVerginadis, IIen
dc.contributor.authorKarkabounas, S.en
dc.contributor.authorSimos, Y.en
dc.contributor.authorKontargiris, E.en
dc.contributor.authorHadjikakou, S. K.en
dc.contributor.authorBatistatou, A.en
dc.contributor.authorEvangelou, A.en
dc.contributor.authorCharalabopoulos, K.en
dc.date.accessioned2015-11-24T19:36:06Z
dc.date.available2015-11-24T19:36:06Z
dc.identifier.issn1879-0720-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23806
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectAntineoplastic Agents/chemistry/*pharmacologyen
dc.subjectApoptosis/drug effectsen
dc.subjectCell Line, Tumoren
dc.subjectDrug Screening Assays, Antitumoren
dc.subjectFemaleen
dc.subjectFlow Cytometryen
dc.subjectHumansen
dc.subjectNeoplasms, Experimental/*pathologyen
dc.subjectNicotinic Acids/chemistry/*pharmacologyen
dc.subjectOrganotin Compounds/chemistry/*pharmacologyen
dc.subjectPlatelet Aggregation/drug effectsen
dc.subjectRatsen
dc.subjectRats, Wistaren
dc.subjectSulfhydryl Compounds/chemistry/*pharmacologyen
dc.titleAnticancer and cytotoxic effects of a triorganotin compound with 2-mercapto-nicotinic acid in malignant cell lines and tumor bearing Wistar ratsen
heal.abstractNowadays, investigation for possible therapeutic applications of various metal-based drugs attracts the scientific interest worldwide. The triorganotin compound bis[triphenyltin(IV)](3-carboxy-pyridine-2-thionato) (SnMNA), was tested for its anti-proliferative and antitumor activities. Cytotoxic activity was assessed by Trypan blue and 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide assay (MTT). SnMNA exhibited potent cytotoxic effects against leiomyosarcoma cells (LMS) and human breast adenocarcinoma cells (MCF-7), which is 200 times stronger than that of cisplatin. Moreover, SnMNA induced significant apoptosis in LMS and MCF-7 cells characterized by flow cytometry analysis and DNA fragmentation. Acute and chronic toxicity studies on Wistar rats caused kidney and lung toxicity at a single dose of 80mg/kgBody Weight (BW) or four repeated doses of 8mg/kgBW once per week. Furthermore, antitumor activity studies on sarcoma bearing Wistar rats revealed that SnMNA complex at four repeated doses of 5.4mg/kgBW every three days prolonged mean survival time of the animal at 200% and decreased mean tumor growth rate (MTGR) compared to the control group (p<0.05). It is noteworthy to mention that the 30% (3 out of 10) of the bearing animals were totally cured. These findings indicate that SnMNA might be a promising new antitumor agent.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.ejps.2010.11.015-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21130873-
heal.identifier.secondaryhttp://www.sciencedirect.com/science/article/pii/S092809871000391X-
heal.journalNameEur J Pharm Scien
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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