High HbF in pregnancy is associated with the Xmn I polymorphism at the -158bp of the G gamma-globin gene
| dc.contributor.author | Lolis, D. | en |
| dc.contributor.author | Georgiou, I. | en |
| dc.contributor.author | Loizou, P. | en |
| dc.contributor.author | Makrydimas, G. | en |
| dc.date.accessioned | 2015-11-24T19:13:49Z | |
| dc.date.available | 2015-11-24T19:13:49Z | |
| dc.identifier.issn | 0301-2115 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21229 | |
| dc.rights | Default Licence | - |
| dc.subject | Deoxyribonucleases, Type II Site-Specific | en |
| dc.subject | Female | en |
| dc.subject | Fetal Hemoglobin/*analysis | en |
| dc.subject | Globins/*genetics | en |
| dc.subject | Heterozygote | en |
| dc.subject | Humans | en |
| dc.subject | *Polymorphism, Restriction Fragment Length | en |
| dc.subject | Pregnancy/*blood | en |
| dc.subject | Pregnancy Trimester, First | en |
| dc.subject | alpha-Fetoproteins/analysis | en |
| dc.subject | beta-Thalassemia/genetics | en |
| dc.title | High HbF in pregnancy is associated with the Xmn I polymorphism at the -158bp of the G gamma-globin gene | en |
| heal.abstract | HbF was measured in the peripheral blood of 354 women during the first trimester of pregnancy. In those (n = 6) with HbF > 3% and in 30 randomly selected pregnant women with normal HbF values, analysis of the G gamma content and the Xmn I polymorphism was performed. The frequency of the Xmn I polymorphism was significantly higher (P < 0.001) in the group with high HbF (0.67) compared to the control group (0.10). The G gamma chain content evaluation revealed a newborn ratio in all 6 high HbF subjects. Six months after delivery, HbF was measured in all women with high HbF during pregnancy, revealing normal values. These results suggest that the presence of the Xmn I polymorphism is a strong inducer for the elevation of HbF during pregnancy. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/7543865 | - |
| heal.journalName | Eur J Obstet Gynecol Reprod Biol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1995 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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